1. Recovery from cortical blindness with mepivacaïne.
- Author
-
Cohen L, Ponchel A, Kas A, Ströer S, Del Cul A, Guérineau de Lamérie G, El Hachem R, Crépin P, and Morin A
- Subjects
- Blindness, Cortical physiopathology, Brain pathology, Cerebral Cortex pathology, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Paroxetine therapeutic use, Stroke physiopathology, Blindness, Cortical drug therapy, Blindness, Cortical etiology, Mepivacaine therapeutic use, Stroke complications
- Abstract
We report the case of a patient suffering from cortical blindness following bilateral occipital stroke, who recovered normal vision in his right visual field following injection of the local anesthetic mepivacaïne. The effect was transient but reproducible, allowing the patient to lead a normal life. Effect duration increased after adjunction of paroxetine. We provide anatomical and functional brain imaging correlates of this improvement, showing particularly how functional connectivity is restored between intact perilesional cortex and distant brain regions. This serendipitous finding may potentially benefit patients suffering from visual but also nonvisual handicap following brain lesions., (© 2019 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association.)
- Published
- 2019
- Full Text
- View/download PDF