1. Interaction between sex and neurofilament light chain on brain structure and clinical severity in Huntington’s disease
- Author
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Sampedro, Frederic, Martinez-Horta, Saul, Pérez-Pérez, Jesús, Pérez-González, Rocío, Horta, Andrea, Campolongo, Antonia, Aracil-Bolaños, Ignacio, Gómez-Ansón, Beatriz, Kulisevsky, Jaime, and Universitat Autònoma de Barcelona
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Neurofilament light ,Neurosciences. Biological psychiatry. Neuropsychiatry ,Disease ,Brief Communication ,Atrophy ,Cerebrospinal fluid ,Sex Factors ,Huntington's disease ,Neurofilament Proteins ,medicine ,Humans ,Clinical severity ,RC346-429 ,business.industry ,General Neuroscience ,Neurodegeneration ,Patient Acuity ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Clinical trial ,Huntington Disease ,Neurology. Diseases of the nervous system ,Neurology (clinical) ,business ,Brief Communications ,RC321-571 - Abstract
Altres ajuts: Huntington's Disease Society of America Female Huntington's disease (HD) patients have consistently shown a faster clinical worsening than male, but the underlying mechanisms responsible for this observation remain unknown. Here, we describe how sex modifies the impact of neurodegeneration on brain atrophy and clinical severity in HD. Cerebrospinal fluid neurofilament light chain (NfL) levels were used as a biological measure of neurodegeneration, and brain atrophy was assessed by structural magnetic resonance imaging. We found that larger NfL values in women reflect higher brain atrophy and clinical severity than in men (p < 0.05 for an interaction model). This differential vulnerability could have important implications in clinical trials.
- Published
- 2021