1. Short-term treatment outcomes in human immunodeficiency virus type-1 and hepatitis B virus co-infections
- Author
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Kwamena W. Sagoe, Francesca Ziga, Max Q. Arens, T.K. Adiku, J. A. A. Mingle, Margaret Lartey, Afrakoma Adjoa Agyei, and Kwabena O. Duedu
- Subjects
Male ,0301 basic medicine ,Longitudinal study ,HIV Infections ,Drug resistance ,medicine.disease_cause ,0302 clinical medicine ,Medical microbiology ,Antiretroviral Therapy, Highly Active ,Longitudinal Studies ,030212 general & internal medicine ,Coinfection ,Human immunodeficiency virus ,Confounding ,virus diseases ,General Medicine ,Middle Aged ,Viral Load ,Hepatitis B ,Co-infection ,Antiretroviral therapy ,Africa, Western ,Treatment Outcome ,Infectious Diseases ,RNA, Viral ,Female ,Viral load ,Adult ,Microbiology (medical) ,Hepatitis B virus ,medicine.medical_specialty ,Genotype ,Short-term therapy ,030106 microbiology ,Antiviral Agents ,03 medical and health sciences ,Sex Factors ,medicine ,Humans ,business.industry ,Research ,medicine.disease ,CD4 Lymphocyte Count ,Immunology ,HIV-1 ,business - Abstract
Background Co-infection of HIV with HBV is common in West Africa but little information is available on the effects of HBV on short-term therapy for HIV patients. A 28 day longitudinal study was conducted to examine short-term antiretroviral therapy (ART) outcomes in HIV infected individuals with HBV co-infection. Methods Plasma from 18 HIV infected individuals co-infected with HBV and matched controls with only HIV infection were obtained at initiation, and 7 and 28 days after ART. HIV-1 viral load changes were monitored. Clinical and demographic data were also obtained from patient folders, and HIV-1 drug resistance mutation and subtype analysis performed. Results The presence of HBV co-infection did not significantly affect HIV-1 viral load changes within 7 or 28 days. The CD4+ counts on the other hand of patients significantly affected the magnitude of HIV-1 viral load decline after 7 days (ρ = −0.441, p = 0.040), while the pre-ART HIV-1 VL (ρ = 0.844, p =
- Published
- 2016
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