1. Epithelioid variant of malignant peripheral nerve sheath tumor (malignant schwannoma) of the urinary bladder
- Author
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William J. Cook, D. Ralph Crowe, Isam A. Eltoum, R. Jemison Moore, Gene P. Siegal, and William H. Rodgers
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Papanicolaou stain ,Malignant peripheral nerve sheath tumor ,Schwannoma ,Pathology and Forensic Medicine ,Diagnosis, Differential ,Immunoenzyme Techniques ,Peripheral Nervous System ,Biomarkers, Tumor ,medicine ,Ascitic Fluid ,Humans ,Peripheral Nerve Sheath ,Hematoma ,Urinary bladder ,business.industry ,Epithelioid Cells ,General Medicine ,medicine.disease ,Primary tumor ,Abscess ,medicine.anatomical_structure ,Urinary Bladder Neoplasms ,Immunohistochemistry ,Sarcoma ,Tomography, X-Ray Computed ,business ,Neurilemmoma - Abstract
Sarcoma represents less than 2% of all neoplasms diagnosed or recognized in effusions. Epithelioid peripheral nerve sheath tumor is a rare tumor that is difficult to differentiate from other epithelioid tumors without the use of ancillary studies. A 39-year-old paraplegic man presented with hematuria and a bladder mass that extended to involve the pelvic peritoneum. Light microscopy using hematoxylin-eosin, Papanicolaou, and immunohistochemical stains as well as transmission electron microscopy showed features of epithelioid malignant peripheral nerve sheath tumor with rhabdoid features and an accompanying eosinophilic infiltrate. Cytologic smears confirmed the similarities between the primary tumor in the bladder and the cells in the pelvic fluid and excluded the possibility of reactive changes related to postsurgical radiation. Ancillary studies were critical in narrowing the differential diagnoses and reaching the final conclusion.
- Published
- 1999
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