1. Measuring senescence rates of patients with end-stage renal disease while accounting for population heterogeneity: an analysis of data from the ERA-EDTA Registry.
- Author
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Koopman JJ, Kramer A, van Heemst D, Åsberg A, Beuscart JB, Buturović-Ponikvar J, Collart F, Couchoud CG, Finne P, Heaf JG, Massy ZA, De Meester JM, Palsson R, Steenkamp R, Traynor JP, Jager KJ, and Putter H
- Subjects
- Age Factors, Aged, Female, Humans, Kidney Failure, Chronic diagnosis, Kidney Failure, Chronic therapy, Kidney Transplantation methods, Linear Models, Logistic Models, Male, Middle Aged, Renal Dialysis methods, Risk Assessment, Sex Factors, Survival Analysis, Aging physiology, Cause of Death, Kidney Failure, Chronic mortality, Kidney Transplantation mortality, Registries, Renal Dialysis mortality
- Abstract
Purpose: Although a population's senescence rate is classically measured as the increase in mortality rate with age on a logarithmic scale, it may be more accurately measured as the increase on a linear scale. Patients on dialysis, who suffer from accelerated senescence, exhibit a smaller increase in their mortality rate on a logarithmic scale, but a larger increase on a linear scale than patients with a functioning kidney transplant. However, this comparison may be biased by population heterogeneity., Methods: Follow-up data on 323,308 patients on dialysis and 91,679 patients with a functioning kidney transplant were derived from the ERA-EDTA Registry. We measured the increases in their mortality rates using Gompertz frailty models that allow individual variation in this increase., Results: According to these models, the senescence rate measured as the increase in mortality rate on a logarithmic scale was smaller in patients on dialysis, while the senescence rate measured as the increase on a linear scale was larger in patients on dialysis than patients with a functioning kidney transplant., Conclusions: Also when accounting for population heterogeneity, a population's senescence rate is more accurately measured as the increase in mortality rate on a linear scale than a logarithmic scale., (Copyright © 2016 Elsevier Inc. All rights reserved.)
- Published
- 2016
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