1. Early leukoencephalopathy during daratumumab treatment in a patient with multiple myeloma.
- Author
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Liu, Shanshan, Zhou, Hongwei, Xu, Weiling, Jin, Tao, Liang, Xinyue, Zhao, Xiaoxia, Dai, Yun, and Jin, Fengyan
- Subjects
DARATUMUMAB ,MULTIPLE myeloma ,DRUG side effects ,IMMUNOGLOBULIN light chains ,PLASMA cell diseases ,LEUKOENCEPHALOPATHIES ,JOHN Cunningham virus - Abstract
Dear Editor, Leukoencephalopathy is a term given to any disorder that affects the white matter in the CNS [[1]]. On August 19, the brain MRI revealed patchy T2/fluid-attenuated inversion recovery (FLAIR) hyperintense signal in bilateral frontal and parietal white matter, centrum semiovale, and corona radiate (Fig. Whereas daratumumab-associated AEs involving CNS are relatively rare (e.g., only one case of progressive multifocal leukoencephalopathy reported thus far in the trials involving daratumumab) [[2]], DRL has been reported in at least three cases [[3]], showing DRL as a late AE after long-term use of daratumumab (Supplemental Table S1). [Extracted from the article]
- Published
- 2023
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