1. Mucosa-associated lymphoid tissue lymphoma with t(11;18)(q21;q21) translocation: long-term follow-up results.
- Author
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Toyoda, Kosuke, Maeshima, Akiko Miyagi, Nomoto, Junko, Suzuki, Tomotaka, Yuda, Sayako, Yamauchi, Nobuhiko, Taniguchi, Hirokazu, Makita, Shinichi, Fukuhara, Suguru, Munakata, Wataru, Maruyama, Dai, Tobinai, Kensei, and Kobayashi, Yukio
- Subjects
MUCOSA-associated lymphoid tissue lymphoma ,FLUORESCENCE in situ hybridization ,GENE fusion ,LYMPHOID tissue ,CHROMOSOMES ,REVERSE transcriptase polymerase chain reaction ,RESEARCH ,CLINICAL trials ,RESEARCH methodology ,B cell lymphoma ,PROGNOSIS ,RETROSPECTIVE studies ,EVALUATION research ,MEDICAL cooperation ,COMPARATIVE studies ,CHROMOSOME abnormalities ,IMPACT of Event Scale ,RESEARCH funding ,POLYMERASE chain reaction ,LONGITUDINAL method - Abstract
Translocation (11;18)(q21;q21) is found in mucosa-associated lymphoid tissue (MALT) lymphoma, resulting in API2/MALT1 gene fusion. It is known that t(11;18)-positive MALT lymphoma shows a tendency to disseminate and be resistant to Helicobacter pylori eradication by antibiotics. However, the prognostic features including recurrence and histological transformation (HT) remain unknown. We conducted a single-institute retrospective analysis of 464 patients with newly diagnosed MALT lymphoma, evaluating the impact of t(11;18) on clinical outcomes. One hundred and six patients were screened for the translocation by fluorescence in situ hybridization and/or reverse transcriptase-polymerase chain reaction. Of these patients, 26 patients (25%) were diagnosed as MALT lymphoma with t(11;18). The patients had a significantly shortened progression-free survival (PFS at 10 years; 26% v 57%; P = 0.004) compared to those without t(11;18). However, this did not translate into overall survival or incidence of HT. We confirmed previous reports stating that t(11;18)-positive MALT lymphoma showed disseminated disease and refractoriness to H. pylori eradication therapy. Patients with t(11;18) had more frequent monoclonal gammopathy, especially of IgM subtype (31% v 8%; P = 0.008), some of which developed class switch. These findings characterize the features of t(11;18)-positive MALT lymphoma, suggesting that it comprises a distinct clinical entity of MALT lymphoma. [ABSTRACT FROM AUTHOR]
- Published
- 2019
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