1. Role of platelets in thrombin generation amongst patients with non-transfusion-dependent thalassaemia
- Author
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Wan Hui Wong, Yiong Huak Chan, Alvin Ren Kwang Tng, Lai Heng Lee, Ai Leen Ang, Hartirathpal Kaur, Chuen Wen Tan, Heng Joo Ng, and Roserahayu Idros
- Subjects
Adult ,Blood Platelets ,Male ,medicine.medical_specialty ,Iron Overload ,medicine.medical_treatment ,Splenectomy ,Thrombin generation ,Gastroenterology ,03 medical and health sciences ,Plasma ,0302 clinical medicine ,Internal medicine ,Medicine ,Humans ,Thrombophilia ,Platelet ,Aged ,Thrombotic risk ,Aged, 80 and over ,Hematology ,business.industry ,Thrombin ,General Medicine ,Middle Aged ,medicine.disease ,Thrombosis ,Coagulation ,030220 oncology & carcinogenesis ,Transfusion dependence ,Thalassemia ,Female ,business ,030215 immunology - Abstract
Non-transfusion-dependent thalassaemia (NTDT) is associated with a hypercoagulable state with thrombotic risk highest after splenectomy. Various mechanisms have been proposed. Although an antiplatelet agent is commonly recommended as thromboprophylaxis in NTDT, the role of platelets contributing to this hypercoagulable state is not well-defined. This study aims to evaluate the role of platelets contributing to hypercoagulability in NTDT patients using thrombin generation (TG). Platelet-rich (PRP) and platelet-poor plasma (PPP) were collected from NTDT patients (n = 30) and normal controls (n = 20) for TG measurement and compared. Controls had higher endogenous thrombin potential (ETP) in PPP (1204.97 nM.min vs 911.62 nM.min, p
- Published
- 2018