1. H. pylori eradication does not reduce paraprotein levels in monoclonal gammopathy of unknown significance (MGUS): a prospective cohort study
- Author
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Pilar García, Juan-Alfonso Soler, Antoni Gavarró, Meritxell Bricullé, Jordi Tena Sánchez, Albert Villoria, Mercé Güell, Xavier Calvet, Javier P. Gisbert, Imma Roig, Servei d'Hematologia, Hospital de Sabadell, Institut Universitari Parc Taulí, Universitat Autònoma de Barcelona (UAB), Servei de Cirurgia, Hospital de Manresa, Althaia, Nefrology Department, Hospital de Sabadell, Institut Universitari Parc Taulí, Departament de Medicina, Laboratori d'Anàlisis Clinics UDIAT-CD Corporació Parc Taulí, Digestive Diseases Unit, Hospital de Sabadell, Institut Universitari Parc Taulí, Departament de Medicina, Instituto de Salud Carlos III [Madrid] (ISC), and Hospital de la Princesa
- Subjects
Male ,medicine.medical_specialty ,Monoclonal gammopathy of unknown significance ,Monoclonal Gammopathy of Undetermined Significance ,Gastroenterology ,Eradication therapy ,Cohort Studies ,03 medical and health sciences ,0302 clinical medicine ,Pharmacotherapy ,immune system diseases ,Clarithromycin ,hemic and lymphatic diseases ,Internal medicine ,medicine ,Humans ,cardiovascular diseases ,Prospective Studies ,Prospective cohort study ,Aged ,030304 developmental biology ,Aged, 80 and over ,0303 health sciences ,Hematology ,Helicobacter pylori ,biology ,business.industry ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,biology.organism_classification ,3. Good health ,Treatment Outcome ,030220 oncology & carcinogenesis ,Immunology ,Cohort ,Female ,business ,Monoclonal gammopathy of undetermined significance ,Follow-Up Studies ,Paraproteins ,Cohort study ,medicine.drug - Abstract
Monoclonal gammopathy of unknown significance (MGUS) is a chronic haematological alteration that carries a 1% risk per year of malignant evolution. The origin of this disturbance remains unknown. Previous reports have suggested that a subgroup of patients presenting MGUS might cure after Helicobacter pylori eradication. This study evaluates the effect of H. pylori eradication in a cohort of 30 patients with MGUS. A 7-day clarithromycin-based triple treatment was prescribed to patients with MGUS infected with H. pylori. Quantification of the monoclonal component was performed at inclusion and at least 12 months after treatment. The monoclonal component persisted unchanged in all patients who cured the H. pylori infection.
- Published
- 2009
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