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Your search keyword '"Plasminogen activator inhibitor-1 (PAI-1)"' showing total 3 results
Start Over Descriptor "Plasminogen activator inhibitor-1 (PAI-1)" Journal annals of hematology
3 results on '"Plasminogen activator inhibitor-1 (PAI-1)"'

1. Alterations of hemostatic parameters in the early development of allogeneic hematopoietic stem cell transplantation-related complications.

Author

Yue Han, Li Zhu, Aining Sun, Xiaoxu Lu, Luping Hu, Lili Zhou, Yongya Ren, Xiaohui Hu, Xiaojin Wu, Zhaoyue Wang, Changgeng Ruan, Depei Wu, Han, Yue, Zhu, Li, Sun, Aining, Lu, Xiaoxu, Hu, Luping, Zhou, Lili, Ren, Yongya, and Hu, Xiaohui

Subjects
*HEMOSTATICS, *GRAFT versus host disease, *HEMATOPOIETIC stem cell transplantation, *COMPLICATIONS from organ transplantation, *EARLY diagnosis, *PLASMINOGEN activators, *FIBRINOGEN, *PROTEIN C, *THROMBOSIS diagnosis, *OPPORTUNISTIC infections, *THROMBOSIS, *RESEARCH, *BLOOD proteins, *HOMOGRAFTS, *TIME, *RESEARCH methodology, *HEMOSTASIS, *DIFFERENTIAL diagnosis, *MEDICAL cooperation, *EVALUATION research, *COMPARATIVE studies, *BLOOD coagulation factors, *TISSUE plasminogen activator, *LONGITUDINAL method
Abstract

Thrombotic events are common and potentially fatal complications in patients receiving hematopoietic stem cell transplantation (HSCT). Early diagnosis is crucial but remains controversial. In this study, we investigated the early alterations of hemostatic parameters in allogeneic HSCT recipients and determined their potential diagnostic values in transplantation-related thrombotic complications and other post-HSCT events. Results from 107 patients with allogeneic HSCT showed higher levels of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and tissue-plasminogen activator (t-PA) and a lower level of plasma protein C after transplantation. No change was found for prothrombin time, antithrombin III, D: -dimer, and activated partial thromboplastin time following HSCT. Transplantation-related complications (TRCs) in HSCT patients were defined as thrombotic (n=8), acute graft-versus-host disease (aGVHD, n=45), and infectious (n=38). All patients with TRCs, especially the patients with thrombotic complications, presented significant increases in the mean and maximum levels of PAI-1 during the observation period. Similarly, a high maximum t-PA level was found in the thrombotic group. In contrast, apparent lower levels of mean and minimum protein C were observed in the TRC patients, especially in the aGVHD group. Therefore, the hemostatic imbalance in the early phase of HSCT, reflecting prothrombotic state and endothelial injury due to the conditioning therapy or TRCs, might be useful in the differential diagnosis of the thrombotic complication from other TRCs. [ABSTRACT FROM AUTHOR]

Published
2011
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3. Alterations of hemostatic parameters in the early development of allogeneic hematopoietic stem cell transplantation-related complications

Author

Changgeng Ruan, Xiaojin Wu, Depei Wu, Zhaoyue Wang, Lili Zhou, Aining Sun, Li-li Zhu, Xiaoxu Lu, Yue Han, Yongya Ren, Luping Hu, and Xiaohui Hu

Subjects
Male, Time Factors, medicine.medical_treatment, Graft vs Host Disease, Hematopoietic stem cell transplantation, 030204 cardiovascular system & hematology, Tissue plasminogen activator, Gastroenterology, chemistry.chemical_compound, 0302 clinical medicine, hemic and lymphatic diseases, Prospective Studies, Child, Plasminogen activator inhibitor-1 (PAI-1), Hematology, medicine.diagnostic_test, Hematopoietic Stem Cell Transplantation, General Medicine, Middle Aged, 3. Good health, Protein C (PC), surgical procedures, operative, 030220 oncology & carcinogenesis, Plasminogen activator inhibitor-1, Tissue Plasminogen Activator, Original Article, Female, Thrombotic complication, medicine.drug, Partial thromboplastin time, Adult, medicine.medical_specialty, Adolescent, Opportunistic Infections, Diagnosis, Differential, 03 medical and health sciences, Young Adult, Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Transplantation, Homologous, Transplantation-related complications (TRCs), Prothrombin time, Hemostasis, business.industry, Fibrinogen, Thrombosis, Transplantation, Early Diagnosis, chemistry, Immunology, Hematopoietic stem cell transplantation (HSCT), business, Protein C
Abstract

Thrombotic events are common and potentially fatal complications in patients receiving hematopoietic stem cell transplantation (HSCT). Early diagnosis is crucial but remains controversial. In this study, we investigated the early alterations of hemostatic parameters in allogeneic HSCT recipients and determined their potential diagnostic values in transplantation-related thrombotic complications and other post-HSCT events. Results from 107 patients with allogeneic HSCT showed higher levels of plasma plasminogen activator inhibitor-1 (PAI-1), fibrinogen, and tissue-plasminogen activator (t-PA) and a lower level of plasma protein C after transplantation. No change was found for prothrombin time, antithrombin III, d-dimer, and activated partial thromboplastin time following HSCT. Transplantation-related complications (TRCs) in HSCT patients were defined as thrombotic (n = 8), acute graft-versus-host disease (aGVHD, n = 45), and infectious (n = 38). All patients with TRCs, especially the patients with thrombotic complications, presented significant increases in the mean and maximum levels of PAI-1 during the observation period. Similarly, a high maximum t-PA level was found in the thrombotic group. In contrast, apparent lower levels of mean and minimum protein C were observed in the TRC patients, especially in the aGVHD group. Therefore, the hemostatic imbalance in the early phase of HSCT, reflecting prothrombotic state and endothelial injury due to the conditioning therapy or TRCs, might be useful in the differential diagnosis of the thrombotic complication from other TRCs.

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