1. The CELSR1 polymorphisms rs6007897 and rs4044210 are associated with ischaemic stroke in Chinese Han population.
- Author
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Zhan, Yi-Hong, Lin, Yi, Tong, Sui-Jun, Ma, Qi-Lin, Lu, Cong-Xia, Fang, Ling, Wei, Wei, Cai, Bin, and Wang, Ning
- Subjects
DISEASE susceptibility ,STROKE ,SINGLE nucleotide polymorphisms ,GENETIC polymorphisms ,GENETICS - Abstract
Background: Recently, CELSR1 was identified by genome-wide association studies (GWAS) as a susceptibility gene for ischaemic stroke (IS) in Japanese individuals. Aim: The goal was to examine whether CELSR1 variants are associated with IS in the Chinese Han population. Subjects and methods: This study genotyped two single nucleotide polymorphisms (SNPs) of CELSR1, rs6007897 and rs4044210, in a Chinese sample of 569 IS cases and 581 controls and assessed their genotype and allele associations with IS. Results: The results showed that rs6007897 and rs4044210 variants of CELSR1 were significantly ( p < 0.01) associated with IS. These associations remained after adjustment for age, gender, smoking status, hypertension, diabetes mellitus and hypercholesterolemia. In addition, a significant association was observed of rs6007897 and rs4044210 of CELSR1 with large artery atherosclerosis (LAA), a sub-type of IS ( p < 0.01). Conclusion: Taken together, the present study has proven for the first time that CELSR1 is a susceptibility gene for IS in the Chinese Han population, especially for LAA. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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