1. Association of ACE, FABP2 and GST genes polymorphism with essential hypertension risk among a North Indian population
- Author
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Syed Tasleem Raza, Farzana Mahdi, Saliha Rizvi, Shania Abbas, Ale Eba, Anu Chandra, and Faisal Ahmed
- Subjects
Adult ,Male ,Aging ,Physiology ,Epidemiology ,India ,Biology ,Peptidyl-Dipeptidase A ,Essential hypertension ,Fatty Acid-Binding Proteins ,Polymerase Chain Reaction ,Polymorphism, Single Nucleotide ,law.invention ,Gene Frequency ,law ,Polymorphism (computer science) ,Genotype ,Multiplex polymerase chain reaction ,Genetics ,medicine ,Humans ,Genetic Predisposition to Disease ,Gene ,Polymerase chain reaction ,Genetic Association Studies ,Glutathione Transferase ,Null (mathematics) ,Public Health, Environmental and Occupational Health ,medicine.disease ,Case-Control Studies ,Hypertension ,Female ,Gene polymorphism ,Essential Hypertension - Abstract
Hypertension has a multi-factorial background based on genetic and environmental interactive factors. ACE, FABP2 and GST genes have been suggested to be involved in the development of hypertension. However, the results have been inconsistent.The present study was carried out to investigate the association of ACE (rs4646994), FABP2 (rs1799883) and GST (GSTM1 null or positive genotype and GSTT1 null or positive genotype) genes polymorphism with essential HTN cases and controls.This study includes 138 essential hypertension (HTN) patients and 116 age-, sex- and ethnicity-matched control subjects. GST (GSTM1 null or positive genotype and GSTT1 null or positive genotype) genes polymorphisms were evaluated by multiplex PCR, ACE (rs4646994) gene polymorphisms by PCR and FABP2 (rs1799883) gene polymorphisms by PCR-RFLP method.Significant differences were obtained in the frequencies of ACE DD, II genotype (p = 0.006, 0.003), GSTT1 null, GSTM1 positive genotype (p = 0.048, 0.010) and FABP2 Ala54/Ala54 genotype (p = 0.049) between essential HTN cases and controls.It is concluded that ACE (rs 4646994), FABP2 (rs1799883) and GST (GSTM1 null or positive genotype and GSTT1 null or positive genotype) genes polymorphism are associated with HTN. Further investigation with a larger sample size may be required to validate this study.
- Published
- 2014