1. Association between mortality and age among mechanically ventilated COVID-19 patients: a Japanese nationwide COVID-19 database study
- Author
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Chie Tanaka, Takashi Tagami, Fumihiko Nakayama, Saori Kudo, Akiko Takehara, Reo Fukuda, Junya Kaneko, Yoshito Ishiki, Shin Sato, Ami Shibata, Masamune Kuno, Kyoko Unemoto, Masayuki Hojo, Tetsuya Mizoue, Yusuke Asai, Setsuko Suzuki, and Norio Ohmagari
- Subjects
COVID-19 ,Age ,Mechanical ventilation ,Mortality ,Medical emergencies. Critical care. Intensive care. First aid ,RC86-88.9 - Abstract
Abstract Background Only a few studies have reported the association between age and mortality in COVID-19 patients who require invasive mechanical ventilation (IMV). We aimed to evaluate the effect of age on COVID-19-related mortality among patients undergoing IMV therapy. Methods This cohort study was conducted using the COVID-19 Registry Japan database, a nationwide multi-centre study of hospitalized patients with laboratory-confirmed COVID-19. Of all 33,808 cases registered between 1 January 2020 to 28 February 2021, we analysed 1555 patients who had undergone IMV. We evaluated mortality rates between age groups using multivariable regression analysis after adjusting for known potential components, such as within-hospital clustering, comorbidities, steroid use, medication for COVID-19, and vital signs on admission, using generalized estimation equation. Results By age group, the mortality rates in the IMV group were 8.6%, 20.7%, 34.9%, 49.7% and 83.3% for patients in their 50s, 60s, 70s, 80s, and 90s, respectively. Multivariable analysis showed that compared with those for patients aged
- Published
- 2021
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