1. Respiratory failure precipitated by high carbohydrate loads.
- Author
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Covelli, Henry D., Black, J. Waylon, Olsen, Michael S., Beekman, Jerome F., Covelli, H D, Black, J W, Olsen, M S, and Beekman, J F
- Subjects
CARBOHYDRATES ,PARENTERAL solutions ,RESPIRATORY insufficiency ,CARBON dioxide ,CARBOHYDRATE content of food ,OBSTRUCTIVE lung diseases ,RESPIRATORY acidosis ,OXYGEN ,PARENTERAL feeding ,DISEASE complications - Abstract
Acute respiratory failure developed in three patients needing ventilatory support within hours after total parenteral nutrition was started. We postulate that the high carbohydrate load provided in the parenteral solution resulted in the use of glucose as the primary energy source, with the development of substantial increases in the carbon dioxide production and the respiratory quotient. Because these patients had a relatively fixed ventilatory response, hypercapnia ensued. Excessive carbohydrate loading may precipitate respiratory acidosis in patients unable to adequately improve their alveolar ventilation when compensating for increased carbon dioxide production. [ABSTRACT FROM AUTHOR]
- Published
- 1981
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