1. Stent-oriented versus patient-oriented outcome in patients undergoing early percutaneous coronary intervention for acute coronary syndrome: 2-year report from the BASE-ACS trial
- Author
-
Antti Ylitalo, Pintoko Tedjokusumo, Adam Debelder, Jussi Mikkelsson, Pasi P. Karjalainen, Hannu Romppanen, Kari Kervinen, Fernando Rivero-Crespo, Mikko Pietilä, Wail Nammas, and Juhani Airaksinen
- Subjects
Male ,Acute coronary syndrome ,medicine.medical_specialty ,medicine.medical_treatment ,Myocardial Infarction ,Myocardial Ischemia ,law.invention ,Percutaneous Coronary Intervention ,Randomized controlled trial ,law ,Internal medicine ,Post-hoc analysis ,medicine ,Humans ,Single-Blind Method ,cardiovascular diseases ,Myocardial infarction ,Everolimus ,Prospective Studies ,Acute Coronary Syndrome ,Prospective cohort study ,Aged ,Sirolimus ,Titanium ,business.industry ,Percutaneous coronary intervention ,Stent ,Drug-Eluting Stents ,General Medicine ,Middle Aged ,equipment and supplies ,medicine.disease ,Surgery ,Patient Outcome Assessment ,Treatment Outcome ,Cardiology ,Female ,Stents ,business ,medicine.drug ,Follow-Up Studies - Abstract
The BASE-ACS trial demonstrated an outcome of the titanium-nitride-oxide-coated bioactive stents (BAS) statistically non-inferior to that of the everolimus-eluting stents (EES) at 12-month follow-up in patients presenting with acute coronary syndrome (ACS). We performed a post hoc analysis of the BASE-ACS trial with particular focus on stent-oriented versus patient-oriented outcome at 24-month follow-up.A total of 827 patients with ACS were randomly assigned to receive either BAS (417) or EES (410). Stent-oriented outcome was defined as a composite of cardiac death, target vessel-related non-fatal myocardial infarction, or ischemia-driven target lesion revascularization. Patient-oriented outcome was defined as a composite of all-cause death, any non-fatal myocardial infarction, or any revascularization.Clinical follow-up for 24 months was completed in 406 (97.4%) patients in the BAS group and in 398 (97.1%) in the EES group. Stent-oriented outcome at 24-month follow-up occurred at similar frequencies in the two stent groups (10.1% for BAS versus 11.2% for EES, P=0.53). Likewise, patient-oriented outcome at 24-month follow-up was similar in the two groups (16.3% versus 19.8%, respectively, P=0.2).In patients presenting with ACS, the rates of both stent-oriented and patient-oriented outcomes at 24-month follow-up in the BAS group were similar to those in the EES group.
- Published
- 2013