1. Arterial stiffness and vascular complications in patients with type 1 diabetes: the Finnish Diabetic Nephropathy (FinnDiane) Study
- Author
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Lena M. Thorn, Tomi Peltola, Outi Heikkilä, Luciano Bernardi, Aino Soro-Paavonen, Johan Wadén, Per-Henrik Groop, Daniel Gordin, Ville-Petteri Mäkinen, Carol Forsblom, Markku Saraheimo, Kustaa Hietala, Nina Tolonen, Milla Rosengård-Bärlund, and Laura Salovaara
- Subjects
Adult ,Male ,medicine.medical_specialty ,Manometry ,030209 endocrinology & metabolism ,030204 cardiovascular system & hematology ,Statistics, Nonparametric ,Nephropathy ,Diabetic nephropathy ,03 medical and health sciences ,0302 clinical medicine ,Vascular Stiffness ,Diabetes mellitus ,Internal medicine ,medicine ,Albuminuria ,Humans ,Diabetic Nephropathies ,Pulse wave velocity ,Finland ,Type 1 diabetes ,business.industry ,General Medicine ,Diabetic retinopathy ,Middle Aged ,medicine.disease ,3. Good health ,Surgery ,Diabetes Mellitus, Type 1 ,Case-Control Studies ,Arterial stiffness ,Cardiology ,Regression Analysis ,Female ,business ,Diabetic Angiopathies ,Retinopathy - Abstract
While patients with type 1 diabetes (T1D) are known to suffer from early cardiovascular disease (CVD), we examined associations between arterial stiffness and diabetic complications in a large patient group with T1D.This study included 807 subjects (622 T1D and 185 healthy volunteers (age 40.6 ± 0.7 versus 41.6 ± 1.2 years; P = NS)). Arterial stiffness was measured by pulse wave analysis from each participant. Furthermore, information on diabetic retinopathy, nephropathy, and CVD was collected. The renal status was verified from at least two out of three urine collections.Patients with T1D without signs of diabetic nephropathy had stiffer arteries measured as the augmentation index (AIx) than age-matched control subjects (17.3% ± 0.6% versus 10.0% ± 1.2%; P0.001). Moreover, AIx (OR 1.08; 95% CI 1.03-1.13; P = 0.002) was associated with diabetic laser-treated retinopathy in patients with normoalbuminuria in a multivariate logistic regression analysis. The same was true for AIx and diabetic nephropathy (1.04 (1.01-1.08); P = 0.004) as well as AIx and CVD (1.06 (1.00-1.12); P = 0.01) in patients with T1D.Arterial stiffness was associated with microvascular and macrovascular complications in patients with T1D.
- Published
- 2010