1. Fingolimod provides long-term protection in rodent models of cerebral ischemia.
- Author
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Ying Wei, Yemisci, Muge, Hyung-HwanKim, Lai Ming Yung, Hwa Kyoung Shin, Seo-Kyoung Hwang, Shuzhen Guo, Tao Qin, Alsharif, Nafiseh, Brinkmann, Volker, Liao, James K., Lo, Eng H., and Waeber, Christian
- Subjects
CEREBRAL ischemia ,LABORATORY rodents ,ANIMAL models of pharmacogenomics ,CEREBRAL arteries ,ARTERIAL occlusions ,INFARCTION - Abstract
The article presents a study which tested the therapeutic effects of fingolimod (FTY720) in rodent models of cerebral ischemia. It evaluates the long-term behavioral outcome of fingolimod, and whether delayed treatment is still effective. The study utilized mouse models of middle cerebral artery occlusion and cell-culture models of neurotoxicity and inflammation. The results showed that fingolimod decreased infarct size and edema, and neuroprotection was associated with reduced inflammation.
- Published
- 2011
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