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Your search keyword '"Elger, Christian E."' showing total 17 results
Start Over Author "Elger, Christian E." Journal annals of neurology
17 results on '"Elger, Christian E."'

1. Getting the best outcomes from epilepsy surgery.

Author

Vakharia, Vejay N, Duncan, John S, Witt, Juri-Alexander, Elger, Christian E, Staba, Richard, and Engel, Jerome

Subjects
Humans, Epilepsy, Treatment Outcome, Neurosurgical Procedures, Clinical Sciences, Neurosciences, Neurology & Neurosurgery
Abstract

Neurosurgery is an underutilized treatment that can potentially cure drug-refractory epilepsy. Careful, multidisciplinary presurgical evaluation is vital for selecting patients and to ensure optimal outcomes. Advances in neuroimaging have improved diagnosis and guided surgical intervention. Invasive electroencephalography allows the evaluation of complex patients who would otherwise not be candidates for neurosurgery. We review the current state of the assessment and selection of patients and consider established and novel surgical procedures and associated outcome data. We aim to dispel myths that may inhibit physicians from referring and patients from considering neurosurgical intervention for drug-refractory focal epilepsies. Ann Neurol 2018;83:676-690.

Published
2018

3. Neuropathological Insights into Unexpected Cognitive Decline in Epilepsy.

Author

Reimers, Annika, Helmstaedter, Christoph, Elger, Christian E., Pitsch, Julika, Hamed, Motaz, Becker, Albert J., and Witt, Juri‐Alexander

Subjects
EPILEPSY, COGNITION disorders, HIPPOCAMPAL sclerosis, EPILEPSY surgery, TEMPORAL lobectomy, PEDIATRIC surgery, NEURODEGENERATION, COGNITIVE development
Abstract

Objective: Some patients unexpectedly display an unfavorable cognitive course after epilepsy surgery subsequent to any direct cognitive sequelae of the surgical treatment. Therefore, we conducted in‐depth neuropathological examinations of resective specimens from corresponding patients to provide insights as to the underlying disease processes. Methods: In this study, cases with significant cognitive deterioration following a previous postoperative assessment were extracted from the neuropsychological database of a longstanding epilepsy surgical program. An extensive reanalysis of available specimens was performed using current, state‐of‐the‐art neuropathological examinations. Patients without cognitive deterioration but matched in regard to basic pathologies served as controls. Results: Among the 355 operated patients who had undergone more than one postoperative neuropsychological examination, 30 (8%) showed significant cognitive decline in the period after surgery. Of the 24 patients with available specimens, 71% displayed further neuropathological changes in addition to the typical spectrum (ie, hippocampal sclerosis, focal cortical dysplasias, vascular lesions, and low‐grade tumors), indicating (1) a secondary, putatively epilepsy‐independent neurodegenerative disease process; (2) limbic inflammation; or (3) the enigmatic pathology pattern of "hippocampal gliosis" without segmental neurodegeneration. In the controls, the matched individual principal epilepsy‐associated pathologies were not found in combination with the secondary pathology patterns of the study group. Interpretation: Our findings indicate that patients who unexpectedly displayed unfavorable cognitive development beyond any direct surgical effects show rare and very particular pathogenetic causes or parallel, presumably independent, neurodegenerative alterations. A multicenter collection of such cases would be appreciated to discern presurgical biomarkers that help with surgical decision‐making. ANN NEUROL 2023;93:536–550 [ABSTRACT FROM AUTHOR]

Published
2023
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6. Drebrin Autoantibodies in Patients with Seizures and Suspected Encephalitis

Author

Pitsch, Julika, primary, Kamalizade, Delara, additional, Braun, Anna, additional, Kuehn, Julia C., additional, Gulakova, Polina E., additional, Rüber, Theodor, additional, Lubec, Gert, additional, Dietrich, Dirk, additional, Wrede, Randi, additional, Helmstaedter, Christoph, additional, Surges, Rainer, additional, Elger, Christian E., additional, Hattingen, Elke, additional, Vatter, Hartmut, additional, Schoch, Susanne, additional, and Becker, Albert J., additional

Published
2020
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7. Reply

Author

Linnebank, Michael, primary, Moskau, Susanna, additional, Semmler, Alexander, additional, Widman, Guido, additional, Stoffel-Wagner, Birgit, additional, Weller, Michael, additional, and Elger, Christian E., additional

Published
2011
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11. Focal cortical dysplasia of Taylor's balloon cell type: Mutational analysis of theTSC1gene indicates a pathogenic relationship to tuberous sclerosis

Author

Becker, Albert J., primary, Urbach, Horst, additional, Scheffler, Björn, additional, Baden, Thomas, additional, Normann, Sabine, additional, Lahl, Rainer, additional, Pannek, Heinz W., additional, Tuxhorn, Ingrid, additional, Elger, Christian E., additional, Schramm, Johannes, additional, Wiestler, Otmar D., additional, and Blümcke, Ingmar, additional

Published
2002
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14. Up-regulation of the metabotropic glutamate receptor mGluR4 in hippocampal neurons with reduced seizure vulnerability

Author

Lie, Ailing A., primary, Becker, Albert, additional, Behle, Karsten, additional, Beck, Heinz, additional, Malitschek, Barbara, additional, Conn, P. Jeffrey, additional, Kuhn, Rainer, additional, Nitsch, Robert, additional, Plaschke, Martina, additional, Schramm, Johannes, additional, Elger, Christian E., additional, Wiestler, Otmar D., additional, and Bl�mcke, Ingmar, additional

Published
2000
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17. Focal cortical dysplasia of Taylor's balloon cell type: Mutational analysis of the TSC1gene indicates a pathogenic relationship to tuberous sclerosis

Author

Becker, Albert J., Urbach, Horst, Scheffler, Björn, Baden, Thomas, Normann, Sabine, Lahl, Rainer, Pannek, Heinz W., Tuxhorn, Ingrid, Elger, Christian E., Schramm, Johannes, Wiestler, Otmar D., and Blümcke, Ingmar

Abstract

Focal cortical dysplasia (FCD) is characterized by a localized malformation of the neocortex and underlying white matter. Balloon cells, similar to those observed in tuberous sclerosis, are present in many cases (FCDbc). In these patients, a hyperintense funnel‐shaped subcortical lesion tapering toward the lateral ventricle was the characteristic finding on fluid‐attenuated inversion recovery magnetic resonance imaging scans. Surgical lesionectomy results in complete seizure relief. Although the pathogenesis of FCDbcremains uncertain, histopathological similarities indicate that FCDbcmay be related pathogenetically to tuberous sclerosis. Here, we studied alterations of the TSC1and TSC2genes in a cohort of patients with chronic, focal epilepsy and histologically documented FCDbc(n = 48). DNA was obtained after microdissection and laser‐assisted isolation of balloon cells, dysplastic neurons, and nonlesional cells from adjacent normal brain tissue. Sequence alterations resulting in amino acid exchange of the TSC1gene product affecting exons 5 and 17 and silent base exchanges in exons 14 and 22 were increased in patients with FCDbccompared with 200 control individuals (exon 5, 2.3% FCDbcvs 0% C; exon 17, 35% FCDbcvs 1.0% C; exon 14, 37.8% FCDbcvs 15% C; exon 22, 45% FCDbcvs 23.8% C). Sequence alterations could be detected in FCDbcand in adjacent normal cells. In 24 patients, DNA was suitable to study loss of heterozygosity at the TSC1gene locus in microdissected FCDbcsamples compared with control tissue. Eleven FCDbccases exhibited loss of heterozygosity. In the TSC2gene, only silent polymorphisms were detected at similar frequencies as in controls. Our findings indicate that FCDbcconstitutes a clinicopathological entity with distinct neuroradiological, neuropathological, and molecular genetic features. These data also suggest a role of the TSC1gene in the development of FCDbcand point toward a pathogenic relationship between FCDbcand the tuberous sclerosis complex.

Published
2002
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