1. Functional brain changes in presymptomatic Huntington's disease
- Author
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Lisa Gourley, Sarah A. J. Reading, Laura A. Peroutka, Mathew Schreiber, Venu Yallapragada, Adam Rosenblatt, Jason Brandt, Elizabeth Aylward, Susan Spear Bassett, Christopher A. Ross, Russell L. Margolis, James J. Pekar, Adam C. Dziorny, and Godfrey D. Pearlson
- Subjects
Adult ,Male ,Population ,Central nervous system ,Disease ,Neuropsychological Tests ,Severity of Illness Index ,Functional Laterality ,Central nervous system disease ,Degenerative disease ,Cognition ,Huntington's disease ,medicine ,Reaction Time ,Humans ,Effects of sleep deprivation on cognitive performance ,education ,education.field_of_study ,Analysis of Variance ,Brain Mapping ,medicine.diagnostic_test ,Brain ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Huntington Disease ,Neurology ,Case-Control Studies ,Female ,Neurology (clinical) ,Psychology ,Functional magnetic resonance imaging ,Cognition Disorders ,Neuroscience - Abstract
Evidence suggests early structural brain changes in individuals with the Huntington's disease (HD) genetic mutation who are presymptomatic for the movement symptoms of the illness. The aim of this study was to investigate the presence of functional brain changes in this same population using functional magnetic resonance imaging. Subjects and matched controls underwent an functional magnetic resonance imaging “interference” protocol, a task known to be mediated in part by corticostriatal circuitry. In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulate cortex (BA 24, 32) compared with matched controls. Ann Neurol 2004;55:879–883
- Published
- 2004