1. Ghrelin is Negatively Correlated with Iron in the Serum in Human and Mice
- Author
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Ming-Dao Mu, Zhong-Ming Qian, Su-Na Huang, Gan Zhou, Yun-Jin Chen, and Qian-Qian Luo
- Subjects
Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Acylation ,Iron ,Medicine (miscellaneous) ,Mice ,Young Adult ,03 medical and health sciences ,Blood serum ,Hepcidin ,Internal medicine ,Animals ,Humans ,Medicine ,Nutrition and Dietetics ,Anemia, Iron-Deficiency ,medicine.diagnostic_test ,biology ,business.industry ,digestive, oral, and skin physiology ,Fasting ,Metabolism ,medicine.disease ,Ghrelin ,Healthy Volunteers ,Pathophysiology ,Mice, Inbred C57BL ,030104 developmental biology ,Endocrinology ,Blood chemistry ,Iron-deficiency anemia ,Serum iron ,biology.protein ,Female ,business ,hormones, hormone substitutes, and hormone antagonists - Abstract
Background/Aims: The studies in the patients with iron deficiency anemia (IDA) implied the existence of the association of ghrelin with iron or hepcidin levels in the plasma under the pathophysiological conditions. We hypothesized that fasting may be able to affect iron metabolism via ghrelin under the physiological conditions. Methods: We investigated the effects of fasting on serum ghrelin and iron contents in healthy volunteers (23–31 years) and C57BL/6 male mice (8-week-olds) under the physiological conditions. Results: Fasting induced a significant elevation in both total ghrelin and acylated ghrelin and a reduction in iron levels in the serum of both human and mice. Correlation analysis demonstrated that total ghrelin or acylated ghrelin is negatively correlated with iron in the serum in human and mice. Conclusion: Ghrelin has a role to reduce serum iron under the conditions of fasting.
- Published
- 2017
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