1. Reshaping preoperative treatment of pancreatic cancer in the era of precision medicine.
- Author
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Casolino R, Braconi C, Malleo G, Paiella S, Bassi C, Milella M, Dreyer SB, Froeling FEM, Chang DK, Biankin AV, and Golan T
- Subjects
- Biomarkers, Tumor genetics, Humans, Neoadjuvant Therapy, Prognosis, Pancreatic Neoplasms surgery, Precision Medicine
- Abstract
This review summarises the recent evidence on preoperative therapeutic strategies in pancreatic cancer and discusses the rationale for an imminent need for a personalised therapeutic approach in non-metastatic disease. The molecular diversity of pancreatic cancer and its influence on prognosis and treatment response, combined with the failure of 'all-comer' treatments to significantly impact on patient outcomes, requires a paradigm shift towards a genomic-driven approach. This is particularly important in the preoperative, potentially curable setting, where a personalised treatment allocation has the substantial potential to reduce pancreatic cancer mortality., Competing Interests: Disclosure The authors have declared no conflicts of interest., (Copyright © 2020 The Authors. Published by Elsevier Ltd.. All rights reserved.) more...
- Published
- 2021
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