6 results on '"Broto JM"'
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2. Soft tissue and visceral sarcomas: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.
- Author
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Casali PG, Abecassis N, Aro HT, Bauer S, Biagini R, Bielack S, Bonvalot S, Boukovinas I, Bovee JVMG, Brodowicz T, Broto JM, Buonadonna A, De Álava E, Dei Tos AP, Del Muro XG, Dileo P, Eriksson M, Fedenko A, Ferraresi V, Ferrari A, Ferrari S, Frezza AM, Gasperoni S, Gelderblom H, Gil T, Grignani G, Gronchi A, Haas RL, Hassan B, Hohenberger P, Issels R, Joensuu H, Jones RL, Judson I, Jutte P, Kaal S, Kasper B, Kopeckova K, Krákorová DA, Le Cesne A, Lugowska I, Merimsky O, Montemurro M, Pantaleo MA, Piana R, Picci P, Piperno-Neumann S, Pousa AL, Reichardt P, Robinson MH, Rutkowski P, Safwat AA, Schöffski P, Sleijfer S, Stacchiotti S, Sundby Hall K, Unk M, Van Coevorden F, van der Graaf WTA, Whelan J, Wardelmann E, Zaikova O, and Blay JY
- Subjects
- Adult, Aftercare methods, Aftercare standards, Antineoplastic Combined Chemotherapy Protocols standards, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biopsy, Europe, Humans, Incidence, Lymphatic Metastasis diagnostic imaging, Lymphatic Metastasis pathology, Magnetic Resonance Imaging methods, Magnetic Resonance Imaging standards, Medical Oncology methods, Neoadjuvant Therapy methods, Neoadjuvant Therapy standards, Neoplasm Grading, Neoplasm Staging, Radiotherapy, Adjuvant methods, Radiotherapy, Adjuvant standards, Sarcoma diagnosis, Sarcoma epidemiology, Sarcoma pathology, Self-Help Groups standards, Societies, Medical standards, Surgical Procedures, Operative methods, Surgical Procedures, Operative standards, Tomography, X-Ray Computed methods, Tomography, X-Ray Computed standards, Treatment Outcome, Medical Oncology standards, Patient Participation, Sarcoma therapy
- Published
- 2018
- Full Text
- View/download PDF
3. Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.
- Author
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Casali PG, Abecassis N, Aro HT, Bauer S, Biagini R, Bielack S, Bonvalot S, Boukovinas I, Bovee JVMG, Brodowicz T, Broto JM, Buonadonna A, De Álava E, Dei Tos AP, Del Muro XG, Dileo P, Eriksson M, Fedenko A, Ferraresi V, Ferrari A, Ferrari S, Frezza AM, Gasperoni S, Gelderblom H, Gil T, Grignani G, Gronchi A, Haas RL, Hassan B, Hohenberger P, Issels R, Joensuu H, Jones RL, Judson I, Jutte P, Kaal S, Kasper B, Kopeckova K, Krákorová DA, Le Cesne A, Lugowska I, Merimsky O, Montemurro M, Pantaleo MA, Piana R, Picci P, Piperno-Neumann S, Pousa AL, Reichardt P, Robinson MH, Rutkowski P, Safwat AA, Schöffski P, Sleijfer S, Stacchiotti S, Sundby Hall K, Unk M, Van Coevorden F, van der Graaf WTA, Whelan J, Wardelmann E, Zaikova O, and Blay JY
- Published
- 2018
- Full Text
- View/download PDF
4. Bone sarcomas: ESMO-PaedCan-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.
- Author
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Casali PG, Bielack S, Abecassis N, Aro HT, Bauer S, Biagini R, Bonvalot S, Boukovinas I, Bovee JVMG, Brennan B, Brodowicz T, Broto JM, Brugières L, Buonadonna A, De Álava E, Dei Tos AP, Del Muro XG, Dileo P, Dhooge C, Eriksson M, Fagioli F, Fedenko A, Ferraresi V, Ferrari A, Ferrari S, Frezza AM, Gaspar N, Gasperoni S, Gelderblom H, Gil T, Grignani G, Gronchi A, Haas RL, Hassan B, Hecker-Nolting S, Hohenberger P, Issels R, Joensuu H, Jones RL, Judson I, Jutte P, Kaal S, Kager L, Kasper B, Kopeckova K, Krákorová DA, Ladenstein R, Le Cesne A, Lugowska I, Merimsky O, Montemurro M, Morland B, Pantaleo MA, Piana R, Picci P, Piperno-Neumann S, Pousa AL, Reichardt P, Robinson MH, Rutkowski P, Safwat AA, Schöffski P, Sleijfer S, Stacchiotti S, Strauss SJ, Sundby Hall K, Unk M, Van Coevorden F, van der Graaf WTA, Whelan J, Wardelmann E, Zaikova O, and Blay JY
- Subjects
- Adult, Aftercare methods, Aftercare standards, Age Factors, Antineoplastic Combined Chemotherapy Protocols standards, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Biopsy, Bone Neoplasms diagnosis, Bone Neoplasms epidemiology, Bone Neoplasms pathology, Bone and Bones diagnostic imaging, Bone and Bones pathology, Bone and Bones surgery, Child, Europe, Humans, Incidence, Long-Term Care methods, Long-Term Care standards, Magnetic Resonance Imaging, Medical Oncology methods, Neoadjuvant Therapy methods, Neoadjuvant Therapy standards, Neoplasm Staging, Orthopedic Procedures methods, Orthopedic Procedures standards, Osteosarcoma diagnosis, Osteosarcoma epidemiology, Osteosarcoma pathology, Positron Emission Tomography Computed Tomography, Radionuclide Imaging, Radiotherapy, Adjuvant methods, Radiotherapy, Adjuvant standards, Self-Help Groups standards, Societies, Medical standards, Survivorship, Treatment Outcome, Bone Neoplasms therapy, Medical Oncology standards, Osteosarcoma therapy, Patient Participation
- Published
- 2018
- Full Text
- View/download PDF
5. Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up.
- Author
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Casali PG, Abecassis N, Aro HT, Bauer S, Biagini R, Bielack S, Bonvalot S, Boukovinas I, Bovee JVMG, Brodowicz T, Broto JM, Buonadonna A, De Álava E, Dei Tos AP, Del Muro XG, Dileo P, Eriksson M, Fedenko A, Ferraresi V, Ferrari A, Ferrari S, Frezza AM, Gasperoni S, Gelderblom H, Gil T, Grignani G, Gronchi A, Haas RL, Hassan B, Hohenberger P, Issels R, Joensuu H, Jones RL, Judson I, Jutte P, Kaal S, Kasper B, Kopeckova K, Krákorová DA, Le Cesne A, Lugowska I, Merimsky O, Montemurro M, Pantaleo MA, Piana R, Picci P, Piperno-Neumann S, Pousa AL, Reichardt P, Robinson MH, Rutkowski P, Safwat AA, Schöffski P, Sleijfer S, Stacchiotti S, Sundby Hall K, Unk M, Van Coevorden F, van der Graaf WTA, Whelan J, Wardelmann E, Zaikova O, and Blay JY
- Subjects
- Adult, Aftercare methods, Aftercare standards, Antineoplastic Combined Chemotherapy Protocols standards, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Chemotherapy, Adjuvant methods, Chemotherapy, Adjuvant standards, Digestive System Surgical Procedures methods, Digestive System Surgical Procedures standards, Endosonography, Europe, Gastrointestinal Stromal Tumors diagnosis, Gastrointestinal Stromal Tumors epidemiology, Gastrointestinal Stromal Tumors pathology, Humans, Image-Guided Biopsy methods, Image-Guided Biopsy standards, Incidence, Intestines diagnostic imaging, Intestines pathology, Intestines surgery, Laparoscopy methods, Laparoscopy standards, Margins of Excision, Medical Oncology methods, Neoplasm Staging, Self-Help Groups standards, Societies, Medical standards, Stomach diagnostic imaging, Stomach pathology, Stomach surgery, Tomography, X-Ray Computed, Treatment Outcome, Gastrointestinal Stromal Tumors therapy, Medical Oncology standards, Patient Participation
- Published
- 2018
- Full Text
- View/download PDF
6. Adjuvant therapy in primary GIST: state-of-the-art.
- Author
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Reichardt P, Blay JY, Boukovinas I, Brodowicz T, Broto JM, Casali PG, Decatris M, Eriksson M, Gelderblom H, Kosmidis P, Le Cesne A, Pousa AL, Schlemmer M, Verweij J, and Joensuu H
- Subjects
- Benzamides, Chemotherapy, Adjuvant, Humans, Imatinib Mesylate, Protein Kinase Inhibitors pharmacology, Protein-Tyrosine Kinases antagonists & inhibitors, Treatment Outcome, Gastrointestinal Neoplasms drug therapy, Gastrointestinal Stromal Tumors drug therapy, Piperazines therapeutic use, Pyrimidines therapeutic use
- Abstract
Background: The management of primary gastrointestinal stromal tumours (GISTs) has evolved with the introduction of adjuvant therapy. Recently reported results of the SSG XVIII/AIO trial by the Scandinavian Sarcoma Group (SSG) and the German Working Group on Medical Oncology (AIO) represent a significant change in the evidence for adjuvant therapy duration. The objectives of this European Expert Panel meeting were to describe the optimal management and best practice for the systemic adjuvant treatment of patients with primary GISTs., Materials and Methods: A panel of medical oncology experts from European sarcoma research groups were invited to a 1-day workshop. Several questions and discussion points were selected by the organising committee prior to the conference. The experts reviewed the current literature of all clinical trials available on adjuvant therapy for primary GISTs, considered the quality evidence and formulated recommendations for each discussion point., Results: Clinical issues were identified and provisional clinical opinions were formulated for adjuvant treatment patient selection, imatinib dose, duration and patient recall, mutational analysis and follow-up of primary GIST patients. Adjuvant imatinib 400 mg/day for 3 years duration is a standard treatment in all patients with significant risk of recurrence following resection of primary GISTs. Patient selection for adjuvant therapy should be based on any of the three commonly used patient risk stratification schemes. R1 surgery (versus R0) alone is not an indication for adjuvant imatinib in low-risk GIST. Recall and imatinib restart could be proposed in patients who discontinued 1-year adjuvant imatinib within the previous 3 months and may be considered on a case-by-case basis in patients who discontinued within the previous year. Mutational analysis is recommended in all cases of GISTs using centralised laboratories with good quality control. Treatment is not recommended in an imatinib-insensitive D842V-mutated GIST. During adjuvant treatment, patients are recommended to be clinically assessed at 1- to 3-month intervals. Upon discontinuation, computed tomography scan (CT) scans are recommended every 3 to 4 months for 2 years when the risk of relapse is highest, followed by every 6 months until year 5 and annually until year 10 after treatment discontinuation., Conclusions: Key points in systemic adjuvant treatment and clinical management of primary GISTs as well as open questions were identified during this European Expert Panel meeting on GIST management.
- Published
- 2012
- Full Text
- View/download PDF
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