1. Coronary arteriopathy in a patient with Noonan phenotype: Case report.
- Author
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Jain, Simran, Ravindra, M. S., Sathe, Yogesh Chintaman, Kulkarni, Snehal M., and Banpurkar, Ashish
- Subjects
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ANEURYSMS , *CONGENITAL heart disease , *AORTIC aneurysms , *INTRACRANIAL aneurysms , *CORONARY disease , *NOONAN syndrome , *PULMONARY stenosis , *AORTIC dissection , *COMPUTED tomography , *CARDIAC hypertrophy , *ATRIAL septal defects , *SINUS of valsalva , *GENETIC mutation , *CORONARY artery disease , *CORONARY angiography , *PHENOTYPES , *ECHOCARDIOGRAPHY , *DISEASE complications , *ADULTS ,CORONARY artery abnormalities - Abstract
Noonan syndrome (NS) is a pleomorphic genetic disorder. Up to 50-80% of individuals have associated congenital heart disease. The scope of cardiac disease in NS is quite variable depending on the gene mutation. The most common forms of cardiac defects include pulmonary stenosis, hypertrophic cardiomyopathy (HCM), atrial septal defect and left-sided lesions. Amongst the rare vascular abnormalities few case reports have been mentioned about coronary artery lesions apart from sinus of Valsalva aneurysm, aortic dissection, intracranial aneurysm. This is a case report a rare case of asymptomatic coronary artery aneurysm in a young male with NS. There is lack of unified protocol for the screening, diagnosis, treatment, and follow-up of coronary artery disease in patients with NS. We conclude, echocardiography is sufficient in most cases in children. But a CT scan is appropriate in adults or when other lesions are suspected. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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