1. Prognostic Significance of Immunohistochemically Detected Blood and Lymphatic Vessel Invasion in Colorectal Carcinoma: Its Impact on Prognosis
- Author
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Akira Takemura, Takeshi Nakachi, Takafumi Tabuchi, Ichiro Nakada, Teruhiko Kasuga, Takanobu Tabuchi, Gyo Motohashi, Pin Liang, and Jian-Wei Hong
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Colorectal cancer ,H&E stain ,CD34 ,Antigens, CD34 ,Surgical oncology ,Lymphatic vessel ,medicine ,Humans ,Neoplasm Invasiveness ,Lymph node ,Aged ,Lymphatic Vessels ,Univariate analysis ,Membrane Glycoproteins ,business.industry ,Middle Aged ,Prognosis ,medicine.disease ,Immunohistochemistry ,medicine.anatomical_structure ,Lymphatic system ,Oncology ,Blood Vessels ,Female ,Surgery ,Colorectal Neoplasms ,business ,Biomarkers - Abstract
The prognostic significance of blood vessel invasion (BVI) and lymphatic vessel invasion (LVI) is unclear. Because of the absence of specific markers for venous and lymphatic vessels, earlier studies could not reliably distinguish between BVI and LVI. By immunostaining for podoplanin and CD34 antigen, we retrospectively investigated LVI and BVI in 419 tissue specimens of colorectal carcinoma. We performed univariate and multivariate analysis of the clinicopathologic features, frequency of recurrence, and outcome of patients with or without LVI and BVI. The use of hematoxylin and eosin (H&E) staining to identify BVI and LVI yielded a false positive rate of 9.1% and false negative rate of 12.6%. The incidence of BVI was significantly higher among tumors with LVI than tumors without LVI (P
- Published
- 2006
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