1. Limited Parathyroidectomy in Multiple Endocrine Neoplasia Type 1-Associated Primary Hyperparathyroidism: A Setup for Failure
- Author
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William F. Simonds, Lee S. Weinstein, Electron Kebebew, Robert T. Jensen, Stephen J. Marx, and Naris Nilubol
- Subjects
Adult ,Male ,Parathyroidectomy ,medicine.medical_specialty ,Adolescent ,endocrine system diseases ,medicine.medical_treatment ,030230 surgery ,Subtotal Parathyroidectomy ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Multiple Endocrine Neoplasia Type 1 ,medicine ,Humans ,Treatment Failure ,Multiple endocrine neoplasia ,Aged ,Neoplasm Staging ,Retrospective Studies ,Hyperparathyroidism ,business.industry ,Retrospective cohort study ,Middle Aged ,Hyperparathyroidism, Primary ,medicine.disease ,Surgery ,medicine.anatomical_structure ,Oncology ,Hypoparathyroidism ,030220 oncology & carcinogenesis ,Female ,Parathyroid gland ,business ,Primary hyperparathyroidism ,Follow-Up Studies - Abstract
Recently, some surgeons have suggested that minimally invasive parathyroidectomy guided by preoperative localizing studies of patients with multiple endocrine neoplasia type 1 (MEN1)-associated primary hyperparathyroidism (pHPT) provides an acceptable outcome while minimizing the risk of hypoparathyroidism. This study aimed to evaluate the outcome for MEN1 patients who underwent limited parathyroidectomy compared with subtotal parathyroidectomy. The authors performed a retrospective analysis of 99 patients with MEN1-associated pHPT who underwent at least one parathyroid operation at their institution. Preoperative imaging studies, intraoperative findings, and clinical outcomes for patients were compared. A total of 99 patients underwent 146 operations. Persistent pHPT was significantly higher in patients whose initial operations involved removal of 1 or 2 glands (69 %) or 2.5 to 3 glands (20 %) compared with those who had 3.5 or more glands removed (6 %) (P
- Published
- 2015
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