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Your search keyword '"Receptor, Serotonin, 5-HT2B"' showing total 12 results
Start Over Descriptor "Receptor, Serotonin, 5-HT2B" Journal annals of the new york academy of sciences
12 results on '"Receptor, Serotonin, 5-HT2B"'

1. Evolutionary Conservation of the 5-HT2BReceptors

Author

Jean-Marie Launay, Doo Sup Choi, Jean François Colas, Luc Maroteaux, Instituto del Mar del Peru (IMARPE), Mayo Clinic, Université Paris Descartes - Paris 5 (UPD5), Biomarqueurs CArdioNeuroVASCulaires (BioCANVAS), Université Paris 13 (UP13)-Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut du Fer à Moulin (IFM - Inserm U1270 - SU), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU), and Maroteaux, Luc

Subjects
MESH: Receptors, Serotonin, [SDV.NEU.NB]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, MESH: Amino Acid Sequence, [SDV.GEN.GA] Life Sciences [q-bio]/Genetics/Animal genetics, Biology, [SDV.BBM.BM] Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, General Biochemistry, Genetics and Molecular Biology, Evolution, Molecular, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, History and Philosophy of Science, Receptor, Serotonin, 5-HT2B, Animals, Humans, MESH: Animals, Amino Acid Sequence, Conserved Sequence, MESH: Evolution, Molecular, MESH: Conserved Sequence, MESH: Humans, General Neuroscience, MESH: Receptor, Serotonin, 5-HT2B, [SDV.NEU.NB] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Neurobiology, [SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Molecular biology, [SDV.MHEP.CSC] Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV.GEN.GA]Life Sciences [q-bio]/Genetics/Animal genetics, Evolutionary biology, Receptors, Serotonin, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, [SDV.SP.PHARMA] Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology, [SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Abstract

International audience

Published
1997

2. Control of bioamine metabolism by 5-HT2B and alpha 1D autoreceptors through reactive oxygen species and tumor necrosis factor-alpha signaling in neuronal cells

Author

Jean-Marie Launay, Myriam Ermonval, Sophie Mouillet-Richard, Odile Kellermann, Benoit Schneider, Mathéa Pietri, and Vincent Mutel

Subjects
Biogenic Amines, Biology, medicine.disease_cause, Serotonergic, General Biochemistry, Genetics and Molecular Biology, Cell Line, Methoxyhydroxyphenylglycol, Norepinephrine, Mice, History and Philosophy of Science, Receptors, Adrenergic, alpha-1, Receptor, Serotonin, 5-HT2B, medicine, Animals, Neurotransmitter metabolism, Receptor, chemistry.chemical_classification, Neurons, Reactive oxygen species, NADPH oxidase, Tumor Necrosis Factor-alpha, General Neuroscience, Cell biology, Biochemistry, chemistry, biology.protein, Signal transduction, Reactive Oxygen Species, Oxidative stress, medicine.drug, Signal Transduction
Abstract

Homeostasis of the central nervous system relies on the proper integration of cell-signaling pathways recruited by a variety of neuronal and non-neuronal factors, with the aim of tightly controlling neurotransmitter metabolism, storage, and transport. We took advantage of the 1C11 neuroectodermal cell line, endowed with the capacity to selectively differentiate into serotonergic (1C11(5-HT)) or noradrenergic (1C11(NE)) neurons, to identify functional targets of serotonin (5-hydroxytryptamine [5-HT]) and norepinephrine (NE) autoreceptors possibly involved in the control of neuronal functions. We demonstrate that 5-HT(2B) and adreno alpha(1D) receptors are coupled to reactive oxygen species (ROS) production through NADPH oxidase activation in 1C11(5-HT) and 1C11(NE) neuronal cells, respectively. In the signaling cascade linking 5-HT(2B) receptors to NADPH oxidase, phospholipase A2-mediated arachidonic acid production is required for ROS synthesis. ROS, in turn, act as second message signals and control the activation of TACE (TNF-alpha converting enzyme), a member of a disintegrin and metalloproteinase family. 5-HT(2B) and alpha(1D) receptor stimulation triggers TACE-dependent TNF-alpha shedding in the surrounding milieu of 1C11(5-HT) and 1C11(NE) cells. In these cells, shed TNF-alpha triggers degradation of 5-HT and NE into 5-HIAA and MHPG, respectively. Finally, we observe that 5-HT(2B) and alpha(1D) receptor couplings to the NADPH oxidase-TACE cascade are strictly restricted to 1C11-derived progenies that have implemented a complete neuronal phenotype. Altogether, our data indicate that couplings of 5-HT(2B) and alpha(1D) autoreceptors to ROS and TNF-alpha signaling control neurotransmitter metabolism in 1C11-derived neuronal cells. Eventually, we might explain the origin of oxidative stress and high level of TNF-alpha in neurodegenerative diseases as a consequence of deviation of normal signaling pathways coupled to neurotransmitters.

Published
2007

3. The 5-HT2B receptor controls the overall 5-HT transport system in the 1C11 serotonergic cell line

Author

Vincent Mutel, Odile Kellermann, Sylvain Loric, and Jean-Marie Launay

Subjects
Imipramine, Serotonin, Nerve Tissue Proteins, Serotonergic, General Biochemistry, Genetics and Molecular Biology, Cell Line, Mice, Text mining, History and Philosophy of Science, Receptor, Serotonin, 5-HT2B, Animals, 5-HT receptor, Serotonin Plasma Membrane Transport Proteins, Membrane Glycoproteins, Chemistry, business.industry, General Neuroscience, Stem Cells, Membrane Transport Proteins, Cell Differentiation, 5-HT2B receptor, Cell biology, Clone Cells, Paroxetine, Cell culture, Receptors, Serotonin, Serotonin Antagonists, business, Carrier Proteins, Transport system
Published
1999

5. 5-HT1Dand 5-HT2BReceptors Mediate Contraction of Smooth Muscle in Human Small Intestine

Author

D. E. Burleigh and R. A. Borman

Subjects
Contraction (grammar), Chemistry, General Neuroscience, Contractile response, General Biochemistry, Genetics and Molecular Biology, Small intestine, Cell biology, medicine.anatomical_structure, History and Philosophy of Science, Smooth muscle, Receptor, Serotonin, 5-HT1D, Receptors, Serotonin, Intestine, Small, Receptor, Serotonin, 5-HT2B, medicine, Humans, Myocyte, Serotonin, medicine.symptom, Receptor, Muscle Contraction, Muscle contraction
Abstract

In conclusion, 5-HT has been shown to contract both circular and longitudinal muscle layers of human terminal ileum. By the use of selective antagonists, the receptors mediating these actions have been identified. In the circular muscle of human small intestine, 5-HT-induced contraction is mediated via a receptor of the 5-HT1D sub-type, whereas a receptor of the 5-HT2B sub-type mediates the contractile response to 5-HT of longitudinal muscle layers.

Published
1997

6. Signaling Pathways and Targets of the 5-HT2B Receptor in the 1C11 Serotonergic Cell Line

Author

Odile Kellermann, Jean-Marie Launay, Claire Tournois, S. Richard, Luc Maroteaux, and Philippe Manivet

Subjects
Serotonin, Cell signaling, Chemistry, Stem Cells, General Neuroscience, Transfection, Serotonergic, Recombinant Proteins, General Biochemistry, Genetics and Molecular Biology, Cell Line, Cell biology, Mice, GTP-binding protein regulators, History and Philosophy of Science, GTP-Binding Proteins, Hes3 signaling axis, Receptors, Serotonin, Receptor, Serotonin, 5-HT2B, Animals, Humans, Stem cell, Signal transduction, Autocrine signalling, Signal Transduction
Published
1998

7. Mouse 5-HT2B receptor-mediated serotonin trophic functions.

Author

Choi DS, Kellermann O, Richard S, Colas JF, Bolaños-Jimenez F, Tournois C, Launay JM, and Maroteaux L

Subjects
Animals, Cell Differentiation, Genes, ras, Mice, Proto-Oncogene Proteins p21(ras) genetics, Receptor, Serotonin, 5-HT2B, Embryonic and Fetal Development, Gene Expression Regulation, Developmental, Receptors, Serotonin genetics, Receptors, Serotonin physiology, Serotonin physiology
Abstract

5-HT2B receptors, in addition to phospholipase C stimulation, are able to trigger activation of the proto-oncogene product p21ras. During mouse embryogenesis, a peak of 5-HT2B receptor expression is detected at the neurulation stage; we localized the 5-HT2B expression in neural crest cells, heart myocardium, and somites. The requirement for functional 5-HT2B receptors shortly after gastrulation, is supported by culture of embryos exposed to 5-HT2B-high affinity antagonist such as ritanserin, which induces morphological defects in the cephalic region, heart and neural tube. Functional 5-HT2B receptors are also expressed during the serotonergic differentiation of the mouse F9 teratocarcinoma-derived clonal cell line 1C11. Upon 2 days of induction by cAMP, 5-HT2B receptors become functional, and on day 4, the appearance of 5-HT2A receptors coincides with the onset of active serotonin transporter by these cells. Active serotonin uptake is modulated by serotonin suggesting autoreceptor functions for 5-HT2B receptors.

Published
1998
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8. The 5-HT2B receptor controls the overall 5-HT transport system in the 1C11 serotonergic cell line.

Author

Launay JM, Loric S, Mutel V, and Kellermann O

Subjects
Animals, Cell Differentiation drug effects, Cell Line, Clone Cells, Imipramine analogs & derivatives, Imipramine pharmacology, Mice, Paroxetine pharmacology, Receptor, Serotonin, 5-HT2B, Receptors, Serotonin drug effects, Serotonin Antagonists pharmacology, Serotonin Plasma Membrane Transport Proteins, Stem Cells cytology, Stem Cells drug effects, Carrier Proteins metabolism, Membrane Glycoproteins metabolism, Membrane Transport Proteins, Nerve Tissue Proteins, Receptors, Serotonin physiology, Serotonin metabolism, Stem Cells physiology
Published
1998
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9. 5-HT2B receptors are expressed by neuronal precursors in the enteric nervous system of fetal mice and promote neuronal differentiation.

Author

Fiorica-Howells E, Maroteaux L, and Gershon MD

Subjects
Animals, Cloning, Molecular, Embryonic and Fetal Development, Fetus, Guinea Pigs, Intestine, Large embryology, Intestine, Large innervation, Intestine, Small embryology, Intestine, Small innervation, Mice, Myenteric Plexus metabolism, Rats, Receptor, Serotonin, 5-HT2B, Receptors, Serotonin analysis, Gene Expression Regulation, Developmental, Myenteric Plexus embryology, Neurons metabolism, Receptors, Serotonin genetics
Published
1998
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12. 5-HT1D and 5-HT2B receptors mediate contraction of smooth muscle in human small intestine.

Author

Borman RA and Burleigh DE

Subjects
Humans, Receptor, Serotonin, 5-HT1D, Receptor, Serotonin, 5-HT2B, Intestine, Small metabolism, Muscle Contraction, Receptors, Serotonin metabolism
Abstract

In conclusion, 5-HT has been shown to contract both circular and longitudinal muscle layers of human terminal ileum. By the use of selective antagonists, the receptors mediating these actions have been identified. In the circular muscle of human small intestine, 5-HT-induced contraction is mediated via a receptor of the 5-HT1D sub-type, whereas a receptor of the 5-HT2B sub-type mediates the contractile response to 5-HT of longitudinal muscle layers.

Published
1997
Full Text
View/download PDF

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