1. POS0270-HPR FLARE-OA QUESTIONNAIRE TO MEASURE FLARES IN OSTEOARTHRITIS OF THE KNEE AND HIP: ASSESSMENT OF ITS PSYCHOMETRIC PROPERTIES
- Author
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Elisabeth Spitz, Camille Alleyrat, Y. Traore, Francis Guillemin, David J. Hunter, Claudia Rutherford, L. March, Leigh F. Callahan, Gillian A. Hawker, L.K. King, J.-F. Maillefert, Bruno Fautrel, Thomas Buttel, C. Ricatte, Jonathan I. Epstein, and Marita Cross
- Subjects
medicine.medical_specialty ,business.industry ,Immunology ,Measure (physics) ,Osteoarthritis ,medicine.disease ,General Biochemistry, Genetics and Molecular Biology ,law.invention ,Rheumatology ,law ,Physical therapy ,medicine ,Immunology and Allergy ,business ,Flare - Abstract
Background:Hip and knee OA is characterised by disease flares – understanding the determinants and consequences of OA flares has been hampered by lack of a standardized flare measure beyond the pain aspect. The patients point of view on the different aspect of their flares is essential.Objectives:The objective was to assess the psychometric properties of a new questionnaire for measuring the multidimensional aspect of flares in OA.Methods:Using a bilingual version of the questionnaire (33 items, response on a numeric scale, from 0 to 10), a multicentre survey (Australia, France and United States) was conducted on line with patients diagnosed with OA of the hip and/or the knee. Based on an international OMERACT/OARSI endorsed definition of the five core domains (pain, swelling, stiffness, consequences of symptoms and psychological aspects) composing a flare in OA [1], a confirmatory factorial analysis linked to the content analysis has been used to reduce the number of items and to determine the validity of the structure. The Flare-OA questionnaire (score from 0 to 100) has been tested in French and English for its internal consistency, its convergent validity with HOOS/KOOS and Mini-OAKHQOL questionnaires, and its discriminant validity.Results:Out of 398 patients (mean age 64 years old) who completed the questionnaire, 70.4% were female and 86.7% had knee OA. The confirmatory factorial analysis retained a model with 19 items (RMSEA =0.06; SRMR =0.04; CFI =0.96 and TLI = 0.94). The Cronbach Alpha was > 0.9 for the 5 domains and for the whole questionnaire. The correlations between the Flare-OA and the other instruments were in line with that hypothesis flare is related but different from other concepts usually measured. The discriminant validity was evidenced by a significant score difference (31.8; pConclusion:The optimized Flare-OA questionnaire (19 items) is a reliable and valid instrument freely available from the authors for measuring the frequency and severity of flare in knee and hip OA in clinical research.References:[1]King LK, Epstein J, Cross M, et al. Establishing the Domains of Knee and Hip Osteoarthritis (OA) Flare: A Report from the OMERACT 2020 Inaugural Virtual Consensus Vote from the Flares in OA Working Group. (Submitted)Disclosure of Interests:None declared
- Published
- 2021