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Your search keyword '"Amino Acid Oxidoreductases toxicity"' showing total 1 results
Start Over Descriptor "Amino Acid Oxidoreductases toxicity" Journal antibiotiki i khimioterapiia antibiotics and chemoterapy sic

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1 results on '"Amino Acid Oxidoreductases toxicity"'

1. [Characteristic effects of L-lysine-alpha-oxidase, an antitumor enzyme produced by Trichoderma sp].

Author

Alekseev SB and Smirnova IP

Subjects
Animals, Capillary Permeability drug effects, Guinea Pigs, Lethal Dose 50, Mice, Rabbits, Rana temporaria, Rats, Skin Irritancy Tests, Toxicity Tests, Chronic, Amino Acid Oxidoreductases toxicity, Antibiotics, Antineoplastic toxicity, Trichoderma enzymology
Abstract

Acute toxicity of L-lysine-alpha-oxidase, an antitumor enzyme of fungal origin was studied. After intravenous administration in a dose of 3000 U/kg the substance induced no signs of intoxication in the laboratory animals or their death. Direct dependence of the vessel permeability increase on the enzyme concentration was determined. In experiments on rabbits and guinea pigs L-lysine-alpha-oxidase showed no local irritating effect.

Published
2007

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