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1. Variations in temperature and oxygen content do not alter levels of thiobarbiturate reactive material in human breast tumour cells (ZR-75-1) incubated with gamma-linolenic acid

Author

R C, Cantrill, G W, Ells, K A, Chisholm, B J, Hughes, and D F, Horrobin

Subjects
Time Factors, Cell Death, Dose-Response Relationship, Drug, Temperature, Breast Neoplasms, Thiobarbiturates, Fluorescence, Linoleic Acid, Oxygen, Linoleic Acids, Tumor Cells, Cultured, Humans, Female, Lipid Peroxidation, Cell Division
Abstract

The mechanism by which tumour cells may be killed in vitro by exogenous polyunsaturated fatty acids may involve lipid peroxidation. Gamma-linolenic acid caused a dose and time-dependent reduction in ZR-75-1 cell growth. However, altering either the incubator temperature (35, 37 and 39 degrees C) or the oxygen content (16, 21 and 26%) had little effect on either the growth of cells in the presence of gamma-linolenic acid or on thiobarbiturate reactive material levels over a 7 day period. Thus, small changes in cell culture conditions do not affect 18:3n-6 cytotoxicity or markers of lipid peroxidation.

Published
1993

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