1. Myofibroblasts correlate with lymphatic microvessel density and lymph node metastasis in early-stage invasive colorectal carcinoma
- Author
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Pin, Liang, Jian-Wei, Hong, Hideyuki, Ubukata, Ge, Liu, Motonobu, Katano, Gyo, Motohashi, Teruhiko, Kasuga, Yoshinori, Watanabe, Ichiro, Nakada, and Takafumi, Tabuchi
- Subjects
Adult ,Aged, 80 and over ,Male ,Membrane Glycoproteins ,Fibroblasts ,Middle Aged ,Immunohistochemistry ,Actins ,Lymphatic Metastasis ,Humans ,Female ,Neoplasm Invasiveness ,Colorectal Neoplasms ,Aged ,Lymphatic Vessels - Abstract
Recent studies have shown that the interactions between tumor cells and stromal cells are important in tumor development. A possible correlation between tumor-activated myofibroblasts, the main component cells of tumor stroma, and lymphatic microvessel density (LMVD) or other clinical parameters in carcinoma was investigated.Immunohistochemical examination of alpha-smooth muscle actin and podoplanin were performed in 83 cases of early-stage invasive colorectal carcinoma.There was a good correlation between proliferation of myofibroblasts (PMpt) and LMVD (LMVDpt) in the peri-tumoral area (p = 0.0034). Increased PMpt was also associated with lymphatic invasion (p = 0.0051) and with lymph node metastasis (p = 0.011). However, proliferation of myofibroblasts in intra-tumoral (PMit) areas was not associated with these clinical parameters.Proliferation of myofibroblasts in peri-tumoral areas seem to play an important role in lymphangiogenesis, and is also associated with lymph node metastasis.
- Published
- 2005