1. Large Animal Models of Glioma: Current Status and Future Prospects.
- Author
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Hicks WH, Bird CE, Pernik MN, Haider AS, Dobariya A, Abdullah KG, Aoun SG, Bentley RT, Cohen-Gadol AA, Bachoo RM, Mickey BE, Pascual JM, and El Ahmadieh TY
- Subjects
- Animals, Biomarkers, Tumor genetics, Biomarkers, Tumor metabolism, Disease Models, Animal, Dogs, Haplorhini, Humans, Mice, Transgenic, Species Specificity, Sus scrofa, Brain Neoplasms genetics, Brain Neoplasms metabolism, Brain Neoplasms pathology, Brain Neoplasms therapy, Glioma genetics, Glioma metabolism, Glioma pathology, Glioma therapy, Translational Research, Biomedical
- Abstract
Enhanced understanding of the molecular features of glioma has led to an expansion of murine glioma models and successful preclinical studies. However, clinical trials continue to have a high cost, extended production time, and low proportion of success. Studies in large-animal models of various cancer types have emerged to bridge the translational gap between in vitro and in vivo animal studies and human clinical trials. The anatomy and physiology of large animals are of more direct relevance to human disease, allowing for more rigorous testing of treatments such as surgical resection and adjuvant therapy in glioma. The recent generation of multiple porcine glioma models supports their use in high-throughput preclinical studies. The demonstration of spontaneous glioblastoma formation in canines further provides a unique avenue for the study of de novo glioma. The aim of this review was to outline the current status of large animal models of glioma and their value as a transitional step between rodent models and human clinical trials., (Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)
- Published
- 2021
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