1. The Intestinal Stem Cell Marker SMOC2 Is an Independent Prognostic Marker Associated With Better Survival in Gastric Cancer
- Author
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Bogun Jang, Hye Sung Kim, Dong Hui Lee, Heung Up Kim, Sung Joon Park, Young Hee Maeng, Chang Lim Hyun, Hyun Joo Song, Young Sil Kim, and Cheol Lee
- Subjects
Male ,Cancer Research ,medicine.medical_specialty ,Perineural invasion ,Stem cell marker ,Gastroenterology ,Stomach Neoplasms ,Internal medicine ,medicine ,Biomarkers, Tumor ,Humans ,Intestinal Mucosa ,Survival analysis ,Aged ,Neoplasm Staging ,Retrospective Studies ,Tissue microarray ,biology ,business.industry ,CD44 ,Calcium-Binding Proteins ,Cancer ,Intestinal metaplasia ,General Medicine ,Cell cycle ,medicine.disease ,Prognosis ,Intestines ,Survival Rate ,Oncology ,biology.protein ,Neoplastic Stem Cells ,Female ,business - Abstract
BACKGROUND/AIM SPARC-related modular calcium-binding protein 2 (SMOC2), a secreted matricellular protein, is reported to be involved in cancer progression such as cell cycle, angiogenesis, and invasion. In this study, we aimed to investigate the expression of SMOC2 in various gastric lesions and assessed its prognostic value in a large cohort of gastric cancer (GC) patients. PATIENTS AND METHODS SMOC2 mRNA levels were measured by quantitative real-time PCR using 26 matched fresh-frozen GC samples. SMOC2 protein expression was determined by immunohistochemistry on tissue microarrays including 734 GC specimens and its correlations with clinicopathological features and survival were evaluated. RESULTS The transcription level of SMOC2 was higher in GC samples compared to normal mucosa (p=0.006). Its expression levels were associated with the intestinal stem cell (ISC) marker, LGR5, but there were no correlations with EPHB2 and OLFM4 or the candidate cancer stem cell markers CD133 and CD44. SMOC2 expression was significantly increased in the intestinal metaplasia and was further increased in gastric adenomas and early gastric cancers (EGC). In total, 34% of GCs were positive for SMOC2, and SMOC2 positivity was higher in old (p=0.001) and male (p
- Published
- 2021