1. Elevated serum 8-OHdG is associated with poor prognosis in epithelial ovarian cancer.
- Author
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Pylväs M, Puistola U, Laatio L, Kauppila S, and Karihtala P
- Subjects
- 8-Hydroxy-2'-Deoxyguanosine, Adenocarcinoma, Clear Cell diagnosis, Adenocarcinoma, Clear Cell surgery, Adenocarcinoma, Mucinous diagnosis, Adenocarcinoma, Mucinous surgery, Adult, Aged, Aged, 80 and over, Cystadenocarcinoma, Serous diagnosis, Cystadenocarcinoma, Serous surgery, Deoxyguanosine blood, Endometrial Neoplasms diagnosis, Endometrial Neoplasms surgery, Enzyme-Linked Immunosorbent Assay, Female, Follow-Up Studies, Humans, Middle Aged, Neoplasm Staging, Ovarian Neoplasms diagnosis, Ovarian Neoplasms surgery, Oxidative Stress, Prognosis, Survival Rate, Adenocarcinoma, Clear Cell blood, Adenocarcinoma, Mucinous blood, Biomarkers, Tumor blood, Cystadenocarcinoma, Serous blood, Deoxyguanosine analogs & derivatives, Endometrial Neoplasms blood, Ovarian Neoplasms blood
- Abstract
Background: 8-Hydroxydeoxyguanosine (8-OHdG) is a marker of oxidative stress in DNA. This study was undertaken to reveal whether serum 8-OHdG could be a prognostic factor in epithelial ovarian carcinoma (EOC)., Patients and Methods: Preoperative serum 8-OHdG levels were examined by enzyme-linked immunosorbent assay in 84 stage I-IV EOC patients. Immunohistochemical (IHC) 8-OHdG expression was determined in 78 of these patients., Results: Strong 8-OHdG immunostaining predicted poor survival. High serum 8-OHdG (>140 pg/ml) was associated with poor ovarian cancer-specific survival (p<0.05) in patients with grade 1-2 EOC (p<0.05), but was not observed among the grade 3 patients. High 8-OHdG levels both in the serum and in the tumour tissue was associated with traditional factors of poor prognosis and serous histology., Conclusion: Both serum and IHC 8-OHdG assessment may serve as prognostic tools in EOC and the role of oxidative stress as a carcinogenic factor in ovarian cancer pathogenesis is also suggested.
- Published
- 2011