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Your search keyword '"M. Kašparová"' showing total 2 results
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2 results on '"M. Kašparová"'

1. Urinary neopterin concentration and toxicity of radiotherapy in patients with head and neck carcinoma during external beam radiation.

Author

Holečková P, Krčmová L, Létal J, Svobodník A, Kalábová H, Kašparová M, Plíšek J, Pála M, Vítek P, Solichová D, Zezulová M, Študentová H, Doležel M, and Melichar B

Subjects
Adult, Aged, Carcinoma, Squamous Cell radiotherapy, Chromatography, High Pressure Liquid, Female, Head and Neck Neoplasms radiotherapy, Humans, Male, Middle Aged, Carcinoma, Squamous Cell urine, Head and Neck Neoplasms urine, Neopterin urine, Radiotherapy adverse effects
Abstract

Aim: Increased serum or urinary concentrations of neopterin are predictive of poor prognosis in patients with tumors across a spectrum of primary locations. Less information is available about the significance of changes of urinary neopterin concentrations during therapy. The aim of the present study was to examine the association between urinary neopterin and toxicity of radiotherapy., Patients and Methods: We analyzed changes of urinary neopterin and toxicity of therapy in 12 patients with head and neck carcinoma during external-beam radiation. Urinary neopterin was determined daily by high-performance liquid chromatography., Results: In addition to a trend for increased neopterin concentrations during radiation therapy, a significant association between changes of neopterin and toxicity and vice versa was observed with a rise of neopterin predicting a later manifestation of toxicity as well as manifestion of toxicity predicting a later rise of neopterin., Conclusion: Urinary neopterin is predictive of toxicity in patients with head and neck carcinoma. An association between toxicity and subsequent rise of urinary neopterin concentrations was also observed.

Published
2013

2. Carotid intima-media thickness and laboratory parameters of atherosclerosis risk in patients with breast cancer.

Author

Melichar B, Kalábová H, Ungermann L, Krčmová L, Hyšpler R, Kašparová M, Pecka M, Šrámek V, Procházková-Študentová H, Svobodník A, Pecen L, and Solichová D

Subjects
Adult, Age Factors, Aged, Atherosclerosis metabolism, Atherosclerosis pathology, Breast Neoplasms metabolism, Breast Neoplasms pathology, C-Reactive Protein metabolism, Female, Fibrinogen metabolism, Humans, Logistic Models, Middle Aged, Neopterin urine, Risk Factors, Tunica Media diagnostic imaging, Tunica Media pathology, Atherosclerosis diagnostic imaging, Breast Neoplasms diagnostic imaging, Carotid Intima-Media Thickness
Abstract

Aim: To investigate the relation between intima-media thickness (IMT) and laboratory parameters of atherosclerosis risk in patients with breast carcinoma., Patients and Methods: IMT and a panel of laboratory parameters associated with the risk of atherosclerosis were studied in 192 patients with histologically-verified breast carcinoma., Results: Patients with metastatic disease had significantly higher fibrinogen, C-reactive protein (CRP), urinary neopterin and mean IMT, and significantly lower serum albumin and hemoglobin concentrations. Significant correlations were observed between CRP, urinary neopterin, mean IMT and other parameters of cardiovascular risk. Age was an independent predictor of the presence of sonographic signs of atherosclerosis using logistic regression, and age, glucose, time from start of chemotherapy, high-density lipoprotein cholesterol, D-dimers were independently associated with IMT in stepwise regression models., Conclusion: In addition to the associations between IMT and laboratory or clinical parameters of the risk of atherosclerosis, IMT may also be associated with the time from chemotherapy.

Published
2012

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