1. Randomized follow-up study of resected NSCLC patients: conventional versus 18F-DG coincidence imaging
- Author
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Monteil, Jacques, Vergnenègre, Alain, Bertin, F., Dalmay, François, Gaillard, Sophie, Bonnaud, F., Melloni, B., Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire [CHU Limoges], CHU Limoges, Neuroépidémiologie Tropicale et Comparée (NETEC), Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST FR CNRS 3503)-Institut d'Epidémiologie Neurologique et de Neurologie Tropicale-Université de Limoges (UNILIM), Laboratoire de Biostatistique et d'Informatique Médicale, Université de Limoges (UNILIM), Service de Pathologie respiratoire et allergologie [CHU Limoges], and Grelier, Elisabeth
- Subjects
Adult ,Male ,Lung Neoplasms ,MESH: Tomography, Emission-Computed ,MESH: Gamma Cameras ,MESH: Aged, 80 and over ,MESH: Fluorodeoxyglucose F18 ,Fluorodeoxyglucose F18 ,Carcinoma, Non-Small-Cell Lung ,Humans ,Gamma Cameras ,Aged ,Neoplasm Staging ,MESH: Aged ,Aged, 80 and over ,MESH: Middle Aged ,MESH: Humans ,MESH: Adult ,MESH: Neoplasm Staging ,MESH: Follow-Up Studies ,Middle Aged ,MESH: Male ,MESH: Lung Neoplasms ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Female ,Neoplasm Recurrence, Local ,Radiopharmaceuticals ,MESH: Neoplasm Recurrence, Local ,MESH: Female ,MESH: Radiopharmaceuticals ,MESH: Carcinoma, Non-Small-Cell Lung ,Follow-Up Studies ,Tomography, Emission-Computed - Abstract
International audience; The aim of this study was to compare the utility of gamma camera using a coincidence detection system imaging (CDET) with 18-fluorodeoxyglucose to conventional imaging techniques in the detection of recurrence of non-small cell lung cancer. Sixty-nine patients were randomized into two groups for follow-up after surgery from October 2000 to December 2002. Each patient was evaluated every 6 months by conventional technique imaging in group A (n=33) or CDET imaging in group B (n=36) over two years. The direct costs of each procedure were evaluated. The major endpoint was the number of recurrences or new tumours detected. The two groups were similar. A total of 25 recurrences was detected (9 in group A and 16 in group B). Overall survival was similar in the two groups. CDET imaging was more expensive. CDET imaging provides earlier detection of recurrence, but does not modify survival outcome. Further studies are necessary to demonstrate the impact, if any, of 18-FDG imaging.
- Published
- 2010