1. Sarcomatous Component in Pancreatic Adenosquamous Carcinoma: A Clinicopathological Series of 7 Cases
- Author
-
Yuichi Goto, Hirohisa Yano, Yoshiki Naito, Shinichi Taniwaki, Hisamune Sakai, Ryuichi Kawahara, Masafumi Yasunaga, Hiroto Ishikawa, Jun Akiba, Hiroyuki Tanaka, Yoriko Nomura, Toru Hisaka, Yoshito Akagi, and Koji Okuda
- Subjects
Male ,Cancer Research ,Poor prognosis ,Pathology ,medicine.medical_specialty ,Vimentin ,Pancreatic Adenosquamous Carcinoma ,Malignancy ,Metastasis ,Carcinoma, Adenosquamous ,medicine ,Humans ,Aged ,biology ,business.industry ,General Medicine ,Middle Aged ,Cadherins ,Prognosis ,medicine.disease ,Sarcomatous Component ,Squamous carcinoma ,Gene Expression Regulation, Neoplastic ,Pancreatic Neoplasms ,Oncology ,biology.protein ,Adenocarcinoma ,Female ,business - Abstract
Background/aim The aim of this study was to examine the clinicopathological features of pancreatic adenosquamous carcinoma (PASC). Patients and methods Our study included seven patients who underwent resection of PASC. Results PASC is characterized by large tumors and strong infiltration into the major blood vessels and other organs, forcing many patients to undergo extended resections. In addition, all patients experienced liver metastasis recurrence following surgery, with a very poor prognosis. Histopathologically, a poorly differentiated sarcomatous component existed in all patients in addition to an adenocarcinoma component and squamous carcinoma component. Although P40 staining for the sarcomatous component was positive along with squamous carcinoma, E-cadherin expression disappeared while vimentin was expressed. It has been suggested that it is highly likely that these sarcomatous components are derived from squamous carcinoma and have an impact on prognosis. Conclusion The sarcomatous component may be related to the biological malignancy of PASC.
- Published
- 2019