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Your search keyword '"Ney Pereira Carneiro dos Santos"' showing total 3 results
Start Over Author "Ney Pereira Carneiro dos Santos" Journal anticancer research
3 results on '"Ney Pereira Carneiro dos Santos"'

1. Investigation of Potentially Deleterious Alleles for Response to Cancer Treatment with 5-Fluorouracil

Author

Giovanna Chaves, Cavalcante, Natalle Do Socorro Da Costa, Freitas, André Maurício, Ribeiro-Dos-Santos, Darlen Cardoso, De Carvalho, Ellen Moreno, Da Silva, Paulo Pimentel, De Assumpção, Ândrea, Ribeiro-Dos-Santos, Sidney, Santos, and Ney Pereira Carneiro, Dos Santos

Subjects
Male, Polymorphism, Genetic, Orotate Phosphoribosyltransferase, Orotidine-5'-Phosphate Decarboxylase, Black People, Antineoplastic Agents, Thymidylate Synthase, White People, Asian People, Gene Frequency, Multienzyme Complexes, Neoplasms, Humans, Female, Fluorouracil, Tumor Suppressor Protein p53, Alleles, Brazil, Dihydrouracil Dehydrogenase (NADP)
Abstract

To investigate polymorphisms that are probable indicators of response variability during cancer treatment with 5-fluorouracil (rs16430, rs2279198, rs1801159 and rs17878362).We investigated 1,038 individuals regarding allele distribution from different populations, out of which we genotyped 127 individuals from a Brazilian admixed population. Similarity analyses with parental populations were performed. Prevalence of potentially deleterious alleles was also evaluated.Thirty-seven percent of the population had at least three potentially deleterious alleles and 38.6% had at least one potentially deleterious allele in homozygosis.Potentially deleterious alleles are present under diverse frequencies in different populations. Therefore, genotyping prior to 5-fluorouracil administration should be recommended.

Published
2015

2. Population stratification effect on cancer susceptibility in an admixed population from Brazilian Amazon

Author

Priscilla Cristina Moura, Vieira, Rommel Mario Rodríguez, Burbano, Débora Christina Ricardo Oliveira, Fernandes, Raquel Carvalho, Montenegro, Sidney Emanuel Batista, Dos Santos, Vinicius Albuquerque, Sortica, Paulo Pimentel, Assumpção, Ândrea Kely Campos, Ribeiro-Dos-Santos, Antônio Alberto, Carvalho, and Ney Pereira Carneiro, Dos Santos

Subjects
Genotype, Black People, Breast Neoplasms, Polymorphism, Single Nucleotide, White People, DNA-Binding Proteins, Genetics, Population, X-ray Repair Cross Complementing Protein 1, Gene Frequency, Risk Factors, Stomach Neoplasms, Humans, Female, Genetic Predisposition to Disease, Brazil, Genetic Association Studies, Methylenetetrahydrofolate Reductase (NADPH2)
Abstract

Many efforts have been made to identify candidate genes involved in cancer susceptibility. The present study aimed to investigate the association between Arg194Trp (XRCC1), Ala222Val (MTHFR) and Arg521Lys (EGFR) polymorphisms (SNPs) and their susceptibility to gastric and breast carcinoma cancer in patients from Brazilian Amazon, controlling population structure interference.The SNPs were genotyped by TaqMan® SNP Genotyping Assays. Ancestry was estimated by analysis of a panel with 48 ancestry informative markers.Logistic regression analysis showed an inverse association with a 10% increase in African and European ancestry and cancer risk (odds ratio (OR)=1.919 and 0.676, respectively). In a preliminary Chi-square analysis a positive association between Arg521Lys (EGFR) polymorphism and carcinoma susceptibility was found (p=0.037); however, when two different methodologies to control population structure bias were utilized, this association was lost (p=0.064 and p=0.256).Genetic ancestry influence gastric and breast cancer risk and highlight the importance of population structure inference in association studies in highly admixed populations, such as those from Brazilian Amazon.

Published
2015

3. Association of slow acetylation profile of NAT2 with breast and gastric cancer risk in Brazil

Author

Marianne Rodrigues, Fernandes, Darlen Cardoso, de Carvalho, Ândrea Kelly Campos Ribeiro, dos Santos, Sidney Emanuel Batista, dos Santos, Paulo Pimentel, de Assumpção, Rommel Mario Rodriguez, Burbano, and Ney Pereira Carneiro, dos Santos

Subjects
Cohort Studies, Base Sequence, Arylamine N-Acetyltransferase, Risk Factors, Stomach Neoplasms, Humans, Acetylation, Breast Neoplasms, Female, Genetic Predisposition to Disease, Polymorphism, Single Nucleotide, Brazil, DNA Primers
Abstract

The N-acetyltransferase 2 (NAT2) gene is a marker for the study of interindividual susceptibility to developing neoplasias. The purpose of this study was to verify a possible association between single nucleotide polymomorphisms (SNPs) of NAT2 and the susceptibility to gastric cancer (GC) and breast cancer (BC) in patients from the North region of Brazil.Five SNPs of the NAT2 gene were investigated by direct sequencing. Ancestry was estimated by analysis of a panel with 48 ancestry-informative markers (AIM).Individuals with slow acetylation profile had an increased risk of developing neoplasias up to three times when compared to controls.In this study, slow acetylation profile was found to strongly influence susceptibility to GC and BC.

Published
2013

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