Search

Your search keyword '"Onozawa, Hisashi"' showing total 3 results
Start Over Author "Onozawa, Hisashi" Journal anticancer research
3 results on '"Onozawa, Hisashi"'

1. The Expression of Immune Checkpoint Receptors and Ligands in the Colorectal Cancer Tumor Microenvironment

Author

NEUPANE, PRAJWAL, primary, MIMURA, KOSAKU, additional, NAKAJIMA, SHOTARO, additional, OKAYAMA, HIROKAZU, additional, ITO, MISATO, additional, THAR MIN, AUNG KYI, additional, SAITO, KATSUHARU, additional, ONOZAWA, HISASHI, additional, FUJITA, SHOTARO, additional, SAKAMOTO, WATARU, additional, SAITO, MOTONOBU, additional, SAZE, ZENICHIRO, additional, MOMMA, TOMOYUKI, additional, and KONO, KOJI, additional

Published
2021
Full Text
View/download PDF

2. Tumor Infiltrating Effector Regulatory T Cells Express VEGF Receptor 2 in Patients With Colorectal Cancer.

Author

Tsumuraya H, Mimura K, Nakajima S, Hanayama H, Matsuishi A, Okayama H, Fukai S, Ito M, Ashizawa M, Chida S, Onozawa H, Sakamoto W, Saito M, Saze Z, Momma T, and Kono K

Subjects
Humans, Male, Female, Aged, Middle Aged, Lymphocytes, Tumor-Infiltrating immunology, Lymphocytes, Tumor-Infiltrating metabolism, Transforming Growth Factor beta1 metabolism, Transforming Growth Factor beta1 genetics, Interleukin-10 genetics, Interleukin-10 metabolism, Forkhead Transcription Factors genetics, Forkhead Transcription Factors metabolism, Colorectal Neoplasms immunology, Colorectal Neoplasms pathology, Colorectal Neoplasms genetics, Colorectal Neoplasms metabolism, T-Lymphocytes, Regulatory immunology, T-Lymphocytes, Regulatory metabolism, Vascular Endothelial Growth Factor Receptor-2 genetics, Vascular Endothelial Growth Factor Receptor-2 metabolism, Vascular Endothelial Growth Factor Receptor-1 genetics, Vascular Endothelial Growth Factor Receptor-1 metabolism, Tumor Microenvironment immunology
Abstract

Background/aim: Regulatory T cells (Tregs) suppress various anti-tumor immune responses in the tumor microenvironment (TME) and their control is considered essential to enhancing efficacy of cancer immunotherapy. The purpose of the study was to evaluate the strategy to regulate Tregs through the vascular endothelial growth factor (VEGF) pathway., Materials and Methods: We evaluated VEGF receptor (VEGFR) expression in subtypes of Tregs by analysis of public databases and through flow cytometry by investigating surgically resected specimens and peripheral blood mononuclear cells (PBMCs) from 26 patients with advanced colorectal cancer (CRC)., Results: Analysis of The Cancer Genome Atlas colorectal adenocarcinoma dataset (n=592) showed that mRNA expression of both FLT1 (VEGFR1) and KDR (VEGFR2) was positively correlated with mRNA expression of FOXP3 as well as Treg signature. Clinical specimens revealed abundant VEGFR2 expression on Tregs, but very marginal VEGFR1 expression. The frequency of effector Tregs, the most immunosuppressive fraction of Tregs, was significantly higher in the tumor than in the PBMC and normal mucosa, and the majority of effector Tregs expressed VEGFR2. Furthermore, by using in vitro generated Tregs, the proportion of Tregs expressing IL-10 or TGF-β1 was significantly inhibited by a VEGFR2 inhibitor., Conclusion: A therapeutic strategy targeting the VEGFR2 axis may have a potential to control effector Tregs in the CRC-TME., (Copyright © 2024 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2024
Full Text
View/download PDF

3. Factors predicting recurrence in patients with Siewert type II carcinoma treated with curative resection.

Author

Fukuchi M, Mochiki E, Suzuki O, Ishiguro T, Sobajima J, Onozawa H, Imaizumi H, Shibata K, Saito K, Naitoh H, Kumagai Y, Ishibashi K, and Ishida H

Subjects
Adenocarcinoma mortality, Adenocarcinoma surgery, Adult, Aged, Aged, 80 and over, Disease-Free Survival, Esophageal Neoplasms mortality, Esophageal Neoplasms surgery, Esophagogastric Junction pathology, Esophagogastric Junction surgery, Female, Humans, Kaplan-Meier Estimate, Lymphatic Metastasis, Male, Middle Aged, Multivariate Analysis, Neoplasm Recurrence, Local mortality, Proportional Hazards Models, Retrospective Studies, Risk Factors, Stomach Neoplasms mortality, Stomach Neoplasms surgery, Adenocarcinoma secondary, Esophageal Neoplasms pathology, Neoplasm Recurrence, Local prevention & control, Stomach Neoplasms pathology
Abstract

Aim: To evaluate the recurrence risk for Siewert type II esophagogastric junction carcinoma treated with curative resection., Patients and Methods: We retrospectively analyzed clinicopathological and recurrence-free survival (RFS) data of 52 patients after curative resection for Siewert type II carcinoma focusing on the role of lymph node metastasis around the greater curvature or parapyloric area., Results: Recurrence was observed in 21 (40%) patients; the median time-to-recurrence was 11 months (range=3-33 months). According to multivariate Cox proportional hazard regression analysis, involvement of nodes no. 4sa, 4sb, 4d, 5 and/or 6 (odds ratio (OR)=6.62; 95% confidence interval (CI)=1.27-41.1; p=0.04) and younger age (OR=2.10; 95% CI=1.25-3.82; p<0.01) were significant independent risk factors affecting RFS., Conclusion: Involvement of no. 4-6 nodes appears to predict recurrence of Siewert type II carcinoma treated with curative resection. Patients with this risk factor may benefit from effective use of perioperative chemotherapy., (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

Catalog

Books, media, physical & digital resources
See catalog results