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Your search keyword '"Pulmonary Blastoma drug therapy"' showing total 2 results
Start Over Descriptor "Pulmonary Blastoma drug therapy" Journal anticancer research
2 results on '"Pulmonary Blastoma drug therapy"'

1. Unresectable Middle Mediastinal Biphasic Pulmonary Blastoma.

Author

Gallo K, Brickman A, Warren WH, Gattuso P, and Seder CW

Subjects
Adult, Cisplatin administration & dosage, Esophageal Neoplasms pathology, Etoposide administration & dosage, Humans, Ifosfamide administration & dosage, Lung Neoplasms pathology, Male, Mediastinal Neoplasms pathology, Neoplasm Staging, Neoplasms, Multiple Primary pathology, Prognosis, Pulmonary Blastoma pathology, Testicular Neoplasms pathology, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Esophageal Neoplasms drug therapy, Lung Neoplasms drug therapy, Mediastinal Neoplasms drug therapy, Neoplasms, Multiple Primary drug therapy, Pulmonary Blastoma drug therapy, Testicular Neoplasms drug therapy
Abstract

We report a case of a young male who presented with an unresectable, centrally-located classic biphasic pulmonary blastoma (CBPB) involving his bilateral mainstem bronchi and esophagus and a synchronous right testicular seminoma. CBPB is a rare and aggressive tumor that most commonly presents as a solitary mass in the periphery of the lung. Surgical resection is the preferred treatment for CBPB, as chemotherapy and radiation have demonstrated limited effectiveness. In the current case, four cycles of cisplatin, ifosfamide, and etoposide with concurrent radiotherapy resulted in a favorable response at three months. Currently he optimal treatment for unresectable pulmonary blastomas remains undefined., (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

2. A rare occurrence of biphasic pulmonary blastoma in an elderly male.

Author

Sharma A, O'Gorman K, Aman C, Rassl D, Mohamid W, and Polychronis A

Subjects
Combined Modality Therapy, Cyclophosphamide therapeutic use, Doxorubicin therapeutic use, Humans, Lung Neoplasms drug therapy, Lung Neoplasms surgery, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasm Metastasis, Pulmonary Blastoma drug therapy, Pulmonary Blastoma surgery, Tomography, X-Ray Computed, Vincristine therapeutic use, Antineoplastic Combined Chemotherapy Protocols therapeutic use, Lung Neoplasms diagnosis, Pulmonary Blastoma diagnosis
Abstract

Pulmonary Blastoma (PB) is a rare primary lung malignancy usually occurring in young to middle aged adults. Surgery is the primary mode of treatment, but survival is poor with the mean 5-year survival being approximately 16%. We report on a case of PB arising in a 63-year-old man. Computed tomography, magnetic resonance imaging and positron emission tomography confirmed the mass to be of pulmonary origin. The morphological appearance combined with the immunoprofile of the tumour was consistent with a poorly-differentiated biphasic pulmonary blastoma. Two months after the surgical resection the patient relapsed with multiple sites of metastasis. The patient was treated with four cycles of cyclophosphamide-, doxorubicin- and vincristine-(CAV)-based chemotherapy, achieving a partial response to treatment. He is currently on a two-monthly review and is recovering from chemotherapy-related toxicities.

Published
2013

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