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Start Over Author "S.-Y. Ying" Journal anticancer research
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1. Activin A inhibits growth and hexamethylene bisacetamide-induced differentiation in human retinoblastoma Y-79 cells

Author

Z, Zhang, Y, Batres, and S Y, Ying

Subjects
Acetamides, Retinoblastoma, Tumor Cells, Cultured, Humans, Antineoplastic Agents, Cell Differentiation, Drug Interactions, Inhibins, Cell Division, Culture Media, Serum-Free, Activins
Abstract

Activin regulates the growth and differentiation of a variety of cells and is a member of the transforming growth factor-beta (TGF-beta) family. Previously, we found that the retinoblastoma cell line Y-79 expresses both activins and activin receptors, suggesting that activin may have an autocrine function in these cells. In this study, the effects of exogeneous activin A on cultured Y-79 cells were examined. The results demonstrate that activin A inhibits hexamethylene bisacetamide (HMBA) -induced Y-79 cell differentiation in both serum-containing and serum-free medium. Activin A also inhibits Y-79 cell growth in serum-containing medium but not in serum-free medium.

Published
1996

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