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Your search keyword '"Shuhei Aoyama"' showing total 2 results
Start Over Author "Shuhei Aoyama" Journal anticancer research
2 results on '"Shuhei Aoyama"'

2. Blood Cell Count Biomarkers Predicting Efficacy of Pembrolizumab as Second-line Therapy for Advanced Urothelial Carcinoma

Author

Chikashi Seto, Taiki Kamijima, Akinobu Takano, Satoshi Yotsuyanagi, Shuhei Aoyama, Rie Fukuda, Hideki Asahi, Kazuyoshi Shigehara, Yoshifumi Kadono, Ryunosuke Nakagawa, Takahiro Nohara, Atsushi Mizokami, Tohru Miyagi, Kouji Izumi, and Shohei Kawaguchi

Subjects
Male, Urologic Neoplasms, Cancer Research, medicine.medical_specialty, Neutrophils, Pembrolizumab, Antibodies, Monoclonal, Humanized, Systemic inflammation, Gastroenterology, Blood cell, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Biomarkers, Tumor, medicine, Humans, Peripheral blood cell, Lymphocytes, Blood markers, Aged, Proportional Hazards Models, Retrospective Studies, Urothelial carcinoma, Aged, 80 and over, Carcinoma, Transitional Cell, Second-line therapy, Proportional hazards model, business.industry, fungi, General Medicine, Middle Aged, Blood Cell Count, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Female, Urothelium, medicine.symptom, business
Abstract

BACKGROUND/AIM To investigate the blood markers for predicting pembrolizumab efficacy in advanced urothelial carcinoma (UC). PATIENTS AND METHODS This study included 91 advanced UC patients. The relationship between prognosis and markers from peripheral blood cell counts, including the neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), and systemic inflammation response index (SIRI=monocytes × neutrophils/lymphocytes), was evaluated. RESULTS Multivariate analysis indicated that pretreatment NLR and the 1-month-change NLR were both significantly associated with overall survival (OS) after pembrolizumab initiation. When the patients were divided into four groups according to calculated cutoffs using Cox proportional hazard model, the pretreatment NLR

Published
2021
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