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Start Over Descriptor "Soluble Vascular Cell Adhesion Molecule 1" Journal anticancer research
2 results on '"Soluble Vascular Cell Adhesion Molecule 1"'

1. Effect of Radiation on the Expression of CVD-related miRNAs, Inflammation and Endothelial Dysfunction of HUVECs

Author

Montserrat Bellés, Meritxell Arenas, Noemí Serra, Victoria Linares, Roser Esplugas, Victor Hernandez, and Joan-Carles Vallvé

Subjects
Cancer Research, DNA, Complementary, medicine.medical_treatment, Vascular Cell Adhesion Molecule-1, Inflammation, Umbilical vein, 03 medical and health sciences, 0302 clinical medicine, microRNA, Cell Adhesion, Human Umbilical Vein Endothelial Cells, Humans, Medicine, Interleukin 8, Endothelial dysfunction, business.industry, Dose-Response Relationship, Radiation, General Medicine, medicine.disease, MicroRNAs, Cytokine, Oncology, Cardiovascular Diseases, 030220 oncology & carcinogenesis, Cancer research, Cytokines, Endothelium, Vascular, medicine.symptom, business, Intracellular, Soluble Vascular Cell Adhesion Molecule 1
Abstract

Background/aim Radiotherapy (RT) can lead to cardiovascular disease (CVD). Evidence suggests that radiation modulates miRNA levels. Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells. Materials and methods Human umbilical vein endothelial cells (HUVECs) were exposed to 2 Gy RT, and intracellular levels of selected miRNAs were measured by real-time polymerase chain reaction at 2 and 24 h. Cytokine and adhesion molecule release were also assessed. Results Results showed that 2 Gy significantly increased the expression of miRNA-221 and miRNA-222, and reduced the level of miRNA-155 after 2 h; whereas miRNA-146a and miRNA-155 were significantly overexpressed and miRNA-222 was significantly down-regulated at 24 h. Interleukin-8 and soluble vascular cell adhesion molecule 1 levels were not affected by the studied RT. Conclusion RT at 2 Gy modulated expression of selected miRNAs by endothelial cells after 2 and 24 h, which might be related to CVD development in patients who receive RT.

Published
2019

2. Effect of Radiation on the Expression of CVD-related miRNAs, Inflammation and Endothelial Dysfunction of HUVECs.

Author

Esplugas R, Bellés M, Serra N, Arenas M, Hernández V, Vallvé JC, and Linares V

Subjects
Cardiovascular Diseases drug therapy, Cardiovascular Diseases radiotherapy, Cell Adhesion, Cytokines metabolism, DNA, Complementary metabolism, Dose-Response Relationship, Radiation, Humans, Vascular Cell Adhesion Molecule-1 metabolism, Cardiovascular Diseases metabolism, Endothelium, Vascular pathology, Human Umbilical Vein Endothelial Cells radiation effects, Inflammation drug therapy, MicroRNAs metabolism, MicroRNAs radiation effects
Abstract

Background/aim: Radiotherapy (RT) can lead to cardiovascular disease (CVD). Evidence suggests that radiation modulates miRNA levels. Our purpose was to assess the acute response to radiation-induced modulation of the expression of miRNA-146a, miRNA-155, miRNA-221, and miRNA-222, inflammatory response and endothelial dysfunction on endothelial cells., Materials and Methods: Human umbilical vein endothelial cells (HUVECs) were exposed to 2 Gy RT, and intracellular levels of selected miRNAs were measured by real-time polymerase chain reaction at 2 and 24 h. Cytokine and adhesion molecule release were also assessed., Results: Results showed that 2 Gy significantly increased the expression of miRNA-221 and miRNA-222, and reduced the level of miRNA-155 after 2 h; whereas miRNA-146a and miRNA-155 were significantly overexpressed and miRNA-222 was significantly down-regulated at 24 h. Interleukin-8 and soluble vascular cell adhesion molecule 1 levels were not affected by the studied RT., Conclusion: RT at 2 Gy modulated expression of selected miRNAs by endothelial cells after 2 and 24 h, which might be related to CVD development in patients who receive RT., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2019
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