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Your search keyword '"Wang, Zhi-hong"' showing total 14 results
Start Over Author "Wang, Zhi-hong" Journal anticancer research
14 results on '"Wang, Zhi-hong"'

3. The Contribution of Matrix Metalloproteinase-7 Promoter Genotypes to Hepatocellular Carcinoma Susceptibility

Author

YUEH, TE-CHENG, primary, TSAO, HAO-YUAN, additional, CHIEN, WEI-CHING, additional, TSAI, CHIA-WEN, additional, PEI, JEN-SHENG, additional, WU, MING-HSIEN, additional, CHEN, CHOU-PIN, additional, CHEN, CHOU-CHEN, additional, WANG, ZHI-HONG, additional, MONG, MEI-CHIN, additional, YANG, YA-CHEN, additional, HUNG, YI-CHIH, additional, BAU, DA-TIAN, additional, and CHANG, WEN-SHIN, additional

Published
2022
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4. The Contribution of Interleukin-8 Rs4073 Genotypes to Triple Negative Breast Cancer Risk in Taiwan

Author

WANG, YUN-CHI, primary, WANG, ZHI-HONG, additional, YEN, JUNG-HSING, additional, SHEN, YI-CHENG, additional, SHEN, TE-CHUN, additional, CHANG, WEN-SHIN, additional, SU, CHEN-HSIEN, additional, CHEN, KAI-YUAN, additional, YEN, CHUN-MING, additional, LEE, HSU-TUNG, additional, YANG, JAI-SING, additional, BAU, DA-TIAN, additional, and TSAI, CHIA-WEN, additional

Published
2022
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6. Contribution of 5-Methyltetrahydrofolate-Homocysteine Methyltransferase Reductase Genotypes to Colorectal Cancer in Taiwan

Author

WU, MING-HSIEN, primary, CHEN, CHAO-HSUAN, additional, CHEN, CHOU-PIN, additional, HUANG, TAI-LIN, additional, YUEH, TE-CHENG, additional, WANG, ZHI-HONG, additional, TSAI, CHIA-WEN, additional, PEI, JEN-SHENG, additional, MONG, MEI-CHIN, additional, YANG, YA-CHEN, additional, BAU, DA-TIAN, additional, and CHANG, WEN-SHIN, additional

Published
2022
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8. Contribution of Interleukin-12A Genotypes to Breast Cancer Risk

Author

WANG, YUN-CHI, primary, WANG, ZHI-HONG, additional, SHEN, TE-CHUN, additional, CHANG, WEN-SHIN, additional, HUANG, SI-ZEIN, additional, YU, CHIEN-CHIH, additional, CHEN, JAW-CHYUN, additional, HSIAU, YU-CHEN, additional, YANG, JAI-SING, additional, TSAI, CHIA-WEN, additional, and BAU, DA-TIAN, additional

Published
2021
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10. The Contribution of MMP-9 Genotypes to Pterygium in Taiwan

Author

TSAI, CHONG-BIN, primary, HSIA, NING-YI, additional, WANG, ZHI-HONG, additional, YANG, JAI-SING, additional, HSU, YUAN-MAN, additional, WANG, YUN-CHI, additional, CHANG, WEN-SHIN, additional, BAU, DA-TIAN, additional, YIN, MEI-CHIN, additional, and TSAI, CHIA-WEN, additional

Published
2020
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12. The Significant Association of MMP-1 Genotypes With Taiwan Pterygium

Author

TSAI, CHONG-BIN, primary, HSIA, NING-YI, additional, WANG, YUN-CHI, additional, WANG, ZHI-HONG, additional, CHIN, YU-TING, additional, HUANG, TAI-LIN, additional, YU, CHIEN-CHIH, additional, CHANG, WEN-SHIN, additional, TSAI, CHIA-WEN, additional, YIN, MEI-CHIN, additional, and BAU, DA-TIAN, additional

Published
2020
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13. Association of Matrix Metalloproteinase-2 Genotypes With Prostate Cancer Risk.

Author

Li PH, Liao CH, Huang WC, Chang WS, Wu HC, Hsu SW, Chen KY, Wang ZH, Hsia TC, Bau DT, and Tsai CW

Subjects
Male, Humans, Genetic Predisposition to Disease, Genotype, Gene Frequency, Case-Control Studies, Polymorphism, Single Nucleotide, Matrix Metalloproteinase 2 genetics, Prostatic Neoplasms genetics
Abstract

Background/aim: Prostate cancer is one of the most commonly diagnosed malignancies among males, especially in Western populations. Matrix metalloproteinase-2 (MMP-2) plays a critical role in extracellular regulation and metastasis. However, its genotypes have seldom been examined among patients with prostate cancer (PCa). Therefore, the purpose of the study was to evaluate the association of genotypes at MMP-2 promoter -1306 (rs243865) and -735 (rs2285053) with PCa risk in a Taiwanese cohort., Materials and Methods: The profiles of MMP-2 rs243865 and rs2285053 genotypes were examined among 218 PCa patients and 436 healthy controls by polymerase chain reaction-restriction fragment length polymorphism methodologies., Results: The percentages of wild-type CC, and variant CT and TT genotypes on MMP-2 rs243865 were 88.5, 10.6, and 0.9% in the PCa case group and 85.6, 13.5, and 0.9% in the control group, respectively (p for trend=0.5544). The allelic frequency distribution showed that the variant T allele at MMP-2 rs24386 5 was not associated with PCa risk (p=0.3250). As for MMP-2 rs2285053, the results were also non-significant. In addition, there was no association between the genotypes of MMP-2 rs243865 or rs2285053 with age or smoking status on PCa risk., Conclusion: rs11568818 and rs11568819 at MMP-2 promoter region played minor roles in determining individual PCa risk., (Copyright © 2023 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2023
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14. Cytotoxic effect of s-petasin and iso-s-petasin on the proliferation of human prostate cancer cells.

Author

Wang ZH, Hsu HW, Chou JC, Yu CH, Bau DT, Wang GJ, Huang CY, Wang PS, and Wang SW

Subjects
Animals, Apoptosis Regulatory Proteins metabolism, Cell Line, Tumor, Drug Screening Assays, Antitumor, Humans, Male, Mice, Prostatic Neoplasms, Stereoisomerism, Antineoplastic Agents, Phytogenic pharmacology, Cell Proliferation drug effects, Sesquiterpenes pharmacology
Abstract

Background: Petasin (Petasides hybridus) is a perennial shrub that is found in Europe as well as parts of Asia and North America and is being used to treat hypertension, tumors and asthma. In a previous study, we reported that petasin possesses biological effects including inhibition of testosterone production and the release of corticosterone from rat zona fasciculata-reticularis cells, and anti-proliferative effect on human T24 bladder carcinoma cells., Materials and Methods: In the present study, we assessed the effects of S-petasin and iso-S-petasin on the growth and proliferation of two hormone-independent DU145 and PC3 and one hormone-dependent LNCaP prostate cancer cell line at concentrations of 10(-7)-10(-5) mol/l. The cell proliferation index, cell number index, expression of caspases and apoptosis-associated proteins and cell morphology were measured., Results: S-Petasin and iso-S-petasin reduced the viable cell number and increased the numbers of apoptotic cells in the tested cell lines in a dose-dependent manner. Western blot analysis revealed that S-petasin and iso-S-petasin reduced the protein levels of procaspase 3, 8, and 9 and cleaved poly(ADP-ribose) polymerase (PARP) in all tested prostate cancer cell lines, and reduced that of procaspase 7 in LNCaP and PC3 cells. At the same time, S-petasin and iso-S-petasin increased mitochondrial membrane permeability and cytochrome c release from mitochondria to the cytosol via reducing the ratio of BCL2/BAX in DU145 and PC3 cells, and up-regulating the levels of p53 in DU145 cells but down-regulating it in PC3 cells., Conclusion: These results indicate that S-petasin and iso-S-petasin induce apoptosis via the activation of mitochondria-related pathways in prostate cancer cells, suggesting S-petasin and iso-S-petasin could be potential anticancer agents., (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)

Published
2015

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