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2. HIV-1 Subtype Is an Independent Predictor of Reverse Transcriptase Mutation K65R in HIV-1 Patients Treated with Combination Antiretroviral Therapy Including Tenofovir

Author

Theys, K., primary, Vercauteren, J., additional, Snoeck, J., additional, Zazzi, M., additional, Camacho, R. J., additional, Torti, C., additional, Schulter, E., additional, Clotet, B., additional, Sonnerborg, A., additional, De Luca, A., additional, Grossman, Z., additional, Struck, D., additional, Vandamme, A.- M., additional, and Abecasis, A. B., additional

Published
2012
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4. HIV-1 subtype is an independent predictor of reverse transcriptase mutation K65R in HIV-1 patients treated with combination antiretroviral therapy including tenofovir.

Author

Theys K, Vercauteren J, Snoeck J, Zazzi M, Camacho RJ, Torti C, Schülter E, Clotet B, Sönnerborg A, De Luca A, Grossman Z, Struck D, Vandamme AM, and Abecasis AB

Subjects
Adenine therapeutic use, Adult, Drug Resistance, Viral genetics, Drug Therapy, Combination, Female, Genetic Variation, HIV Infections drug therapy, HIV Infections virology, HIV-1 classification, HIV-1 drug effects, HIV-1 enzymology, HIV-1 genetics, Humans, Male, Middle Aged, Molecular Sequence Data, RNA-Directed DNA Polymerase genetics, Reverse Transcriptase Inhibitors pharmacology, Tenofovir, Adenine analogs & derivatives, Anti-HIV Agents therapeutic use, HIV Reverse Transcriptase genetics, Organophosphonates therapeutic use, Reverse Transcriptase Inhibitors therapeutic use
Abstract

Subtype-dependent selection of HIV-1 reverse transcriptase resistance mutation K65R was previously observed in cell culture and small clinical investigations. We compared K65R prevalence across subtypes A, B, C, F, G, and CRF02_AG separately in a cohort of 3,076 patients on combination therapy including tenofovir. K65R selection was significantly higher in HIV-1 subtype C. This could not be explained by clinical and demographic factors in multivariate analysis, suggesting subtype sequence-specific K65R pathways.

Published
2013
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