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Start Over Descriptor "Acetyltransferases pharmacology" Journal antimicrobial agents and chemotherapy

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1. Enzymatic method for inactivation of aminoglycosides during measurement of postantibiotic effect.

Author

den Hollander JG, Mouton JW, Bakker-Woudenberg IA, Vleggaar FP, van Goor MP, and Verbrugh HA

Subjects
Bacteria drug effects, Gentamicins metabolism, Tobramycin metabolism, Acetyltransferases pharmacology, Anti-Bacterial Agents metabolism, Bacteria metabolism, Microbial Sensitivity Tests methods
Abstract

To determine the postantibiotic effect of aminoglycosides, two methods are currently being used to remove the test drug: repeated washing and dilution. An enzymatic inactivation method of removing gentamicin and tobramycin was developed and compared with the dilution method. This enzymatic method provides a rapid and simple alternative method of removing aminoglycosides which results in reliable postantibiotic-effect values.

Published
1996
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