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1. Sesquiterpene farnesol contributes to increased susceptibility to β-lactams in strains of Burkholderia pseudomallei.

Author

Brilhante RS, Valente LG, Rocha MF, Bandeira TJ, Cordeiro RA, Lima RA, Leite JJ, Ribeiro JF, Pereira JF, Castelo-Branco DS, Monteiro AJ, and Sidrim JJ

Subjects
Burkholderia pseudomallei growth & development, Drug Resistance, Bacterial, Drug Synergism, Microbial Sensitivity Tests, beta-Lactamases metabolism, Anti-Bacterial Agents pharmacology, Burkholderia pseudomallei drug effects, Farnesol pharmacology, beta-Lactams pharmacology
Abstract

This study aimed to evaluate the in vitro combination of farnesol and β-lactams against Burkholderia pseudomallei. A total of 12 β-lactamase-positive strains were tested according to CLSI standards. All strains were inhibited by farnesol, with MICs ranging from 75 to 150 μM. The combination of this compound with β-lactams resulted in statistically significant β-lactam MIC reduction (P ≤ 0.05). This study provides new perspectives for the use of farnesol combined with β-lactam antibiotics against strains of B. pseudomallei.

Published
2012
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