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Your search keyword '"Ekaza, Euloge"' showing total 2 results
Start Over Author "Ekaza, Euloge" Journal antimicrobial agents and chemotherapy
2 results on '"Ekaza, Euloge"'

1. High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis

Author

Silva-Miranda, Mayra, primary, Ekaza, Euloge, additional, Breiman, Adrien, additional, Asehnoune, Karim, additional, Barros-Aguirre, David, additional, Pethe, Kevin, additional, Ewann, Fanny, additional, Brodin, Priscille, additional, Ballell-Pages, Lluís, additional, and Altare, Frédéric, additional

Published
2015
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2. High-Content Screening Technology Combined with a Human Granuloma Model as a New Approach To Evaluate the Activities of Drugs against Mycobacterium tuberculosis

Author

Silva-Miranda, Mayra, Ekaza, Euloge, Breiman, Adrien, Asehnoune, Karim, Barros-Aguirre, David, Pethe, Kevin, Ewann, Fanny, Brodin, Priscille, Ballell-Pages, Lluís, and Altare, Frédéric

Abstract

ABSTRACTTuberculosis remains a major health problem due to the emergence of drug-resistant strains of Mycobacterium tuberculosis. Some models have provided valuable information about drug resistance and efficacy; however, the translation of these results into effective human treatments has mostly proven unsuccessful. In this study, we adapted high-content screening (HCS) technology to investigate the activities of antitubercular compounds in the context of an in vitrogranuloma model. We observed significant shifts in the MIC50s between the activities of the compounds under extracellular and granuloma conditions.

Published
2014
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