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Your search keyword '"Menchinelli G."' showing total 3 results
Start Over Author "Menchinelli G." Journal antimicrobial agents and chemotherapy
3 results on '"Menchinelli G."'

2. Efficient Inactivation of Clinically Relevant Antimicrobial Drug Concentrations by BacT/Alert or Bactec Resin-Containing Media in Simulated Adult Blood Cultures.

Author

Menchinelli G, Liotti FM, Giordano L, De Angelis G, Sanguinetti M, Spanu T, and Posteraro B

Subjects
Adult, Bacteremia microbiology, Bacteria drug effects, Culture Media chemistry, Escherichia coli drug effects, Escherichia coli isolation & purification, Humans, Meropenem pharmacology, Pseudomonas aeruginosa isolation & purification, Time Factors, Anti-Bacterial Agents pharmacology, Bacteria isolation & purification, Blood Culture methods, Culture Media pharmacology
Abstract

We assessed the antimicrobial-inactivation capability of BacT/Alert (FA Plus and FN Plus) or Bactec (Plus Aerobic/F and Plus Anaerobic/F) media for 40 antibiotic-bacterium combinations in simulated adult blood cultures. Aside from high recovery rates (93.2% and 88.4%, respectively), we showed that at the lowest but clinically relevant antibiotic concentrations, both BacT/Alert and Bactec media recovered all the organisms tested with drugs except for Escherichia coli , which was tested in the presence of meropenem. Delayed recoveries were mainly associated with vancomycin., (Copyright © 2019 American Society for Microbiology.)

Published
2019
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3. Simplified Testing Method for Direct Detection of Carbapenemase-Producing Organisms from Positive Blood Cultures Using the NG-Test Carba 5 Assay.

Author

Giordano L, Fiori B, D'Inzeo T, Parisi G, Liotti FM, Menchinelli G, De Angelis G, De Maio F, Luzzaro F, Sanguinetti M, Posteraro B, and Spanu T

Subjects
Blood Culture methods, Enterobacteriaceae metabolism, Humans, Klebsiella pneumoniae metabolism, Microbial Sensitivity Tests methods, Sensitivity and Specificity, Bacterial Proteins metabolism, Bacteriological Techniques methods, Enterobacteriaceae Infections diagnosis, Enterobacteriaceae Infections microbiology, beta-Lactamases metabolism
Abstract

We directly tested 484 organisms from clinical ( n  = 310) and simulated ( n  = 174) positive blood cultures using the NG-Test Carba 5 assay for carbapenemase-producing Enterobacterales detection. The assay identified all but 4 of the KPC (170/171), OXA-48-like (22/22), VIM (19/21), and NDM (14/15) producers with no false positives. Among the clinical Klebsiella pneumoniae organisms tested, 122 of 123 KPC, 1 of 1 OXA-48-like, and 1 of 2 VIM producers were detected by the assay. Some VIM and NDM producers yielded scant but still-readable bands with the assay. No organisms produced the IMPs that the assay was designed to detect., (Copyright © 2019 American Society for Microbiology.)

Published
2019
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