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Start Over Author "Ullmann, Andrew" Journal antimicrobial agents and chemotherapy
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5. In VitroEvaluation of Radiolabeled Amphotericin B for Molecular Imaging of Mold Infections

Author

Page, Lukas, Ullmann, Andrew J., Schadt, Fabian, Wurster, Sebastian, and Samnick, Samuel

Abstract

Invasive pulmonary aspergillosis and mucormycosis are life-threatening complications in immunocompromised patients. A rapid diagnosis followed by early antifungal treatment is essential for patient survival. Given the limited spectrum of biomarkers for invasive mold infections, recent studies have proposed the use of radiolabeled siderophores or antibodies as molecular probes to increase the specificity of radiological findings by nuclear imaging modalities. While holding enormous diagnostic potential, most of the currently available molecular probes are tailored to the detection of Aspergillusspecies, and their cost-intensive and sophisticated implementation restricts their accessibility at less specialized centers.

Published
2020
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