1. Modulation of T Cell Activation in Obesity
- Author
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Stéphanie O. Morin, Marie-Christine Alessi, Marjorie Poggi, Jean-François Landrier, Jacques A. Nunès, Centre de Recherche en Cancérologie de Marseille (CRCM), Aix Marseille Université (AMU)-Institut Paoli-Calmettes, Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Fédération nationale des Centres de lutte contre le Cancer (FNCLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Nutrition, obésité et risque thrombotique (NORT), Institut National de la Recherche Agronomique (INRA)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU) - Institut Paoli-Calmettes - Institut National de la Santé et de la Recherche Médicale (INSERM) - Centre National de la Recherche Scientifique (CNRS), Université de la Méditerranée - Aix-Marseille 2 - Institut National de la Recherche Agronomique (INRA) - Aix Marseille Université (AMU) - Institut National de la Santé et de la Recherche Médicale (INSERM), Fondation pour la Recherche Medicale FRM DEQ20140329534, and Aix Marseille Université (AMU)-Institut National de la Recherche Agronomique (INRA)-Institut National de la Santé et de la Recherche Médicale (INSERM)
- Subjects
0301 basic medicine ,Cell signaling ,CD28 ,[SDV.IMM] Life Sciences [q-bio]/Immunology ,Physiology ,T cell ,Cellular differentiation ,T-Lymphocytes ,Clinical Biochemistry ,Antigen presentation ,T cells ,Cell Communication ,Biology ,Lymphocyte Activation ,Biochemistry ,liver steatosis ,Immunomodulation ,03 medical and health sciences ,Mice ,Immune system ,medicine ,Animals ,Humans ,IL-2 receptor ,Obesity ,CD154 ,Vitamin D ,Molecular Biology ,ComputingMilieux_MISCELLANEOUS ,General Environmental Science ,Inflammation ,high fat diet ,Cell Differentiation ,Cell Biology ,[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolism ,Cell biology ,[SDV.AEN] Life Sciences [q-bio]/Food and Nutrition ,030104 developmental biology ,medicine.anatomical_structure ,costimulation ,Immunology ,General Earth and Planetary Sciences ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Biomarkers ,Transcription Factors - Abstract
International audience; SIGNIFICANCE: Immune T cells are present in adipose tissues (AT), and the stoichiometry of the different T cell subsets is altered during diet-induced obesity (DIO). T cells contribute to the early steps of AT inflammation during DIO. Recent Advances: Many factors could potentially be responsible for this altered pro-inflammatory versus anti-inflammatory T cell balance.CRITICAL ISSUES: T cells are potentially activated in AT, which vitamin D might contribute to, as will be discussed in this article. In addition, we will review the different possible contributors to T cell activation in AT, such as the CD28 and CD154 T cell costimulatory molecules in AT.FUTURE DIRECTIONS: The potential antigen presentation capacities of adipocytes should be further investigated. Moreover, the properties of these AT resident (or migrating to AT) T cells must be further assessed. Antioxid. Redox Signal. 26, 489-500.
- Published
- 2016
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